Juventus pair Alvaro Morata with Cristiano Ronaldo and Federico Chiesa, while Sampdoria use Fabio Quagliarella and Keita Balde Diao.
You can follow all the build-up and action as it happens from this game, Bologna–Milan and Inter-Benevento on the LIVEBLOG.
It kicks off at the Stadio Luigi Ferraris at 17.00 GMT.
Juventus pair Alvaro Morata with Cristiano Ronaldo and Federico Chiesa, while Sampdoria use Fabio Quagliarella and Keita Balde Diao.
It kicks off at the Stadio Luigi Ferraris at 17.00 GMT.
Both teams are finding their form recently, as the Bianconeri won the Italian Supercup against Napoli, closed the gap on the Serie A leaders – with a game in hand – and booked their spot in Tuesday’s Coppa Italia semi-final with Inter.
Dejan Kulusevski is suspended, with Paulo Dybala still out injured, but Matthijs de Ligt and Alex Sandro have recovered from COVID-19 now and are both benched.
Morata partners Ronaldo, with Chiesa and Weston McKennie taking the wide roles.
Sampdoria are coming off two consecutive victories too, despite missing Manolo Gabbiadini to a long-term injury.
Fabio Quagliarella and Keita Balde Diao lead the attack together, despite reports one would be dropped in favour of Gaston Ramirez.
Omar Colley returns in defence and Antonio Candreva is eager to impress on the right flank, with Adrien Silva again in midfield.
Sampdoria: Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Thorsby, Ekdal, Silva; Keita Balde, Quagliarella
Juventus: Szczesny; Cuadrado, Bonucci, Chiellini, Danilo; Chiesa, Arthur, Bentancur, McKennie; Morata, Ronaldo
Ref: Fabbri