Sampdoria aim to continue their strong run against a Lazio side burned by the Rome Derby, as this game is all about the strikers.
It kicks off at Marassi at 19.45 GMT, follow the build-up and action on the Liveblog.
The hosts are unbeaten in five, including victories over Inter and Torino, so confidence is sky-high for the Blucerchiati.
Sampdoria aim to continue their strong run against a Lazio side burned by the Rome Derby, as this game is all about the strikers.
It kicks off at Marassi at 19.45 GMT, follow the build-up and action on the Liveblog.
The hosts are unbeaten in five, including victories over Inter and Torino, so confidence is sky-high for the Blucerchiati.
Emiliano Viviano, Jacopo Sala, Daniel Pavlovic and Carlos Carbonero are long-term absentees, while Antonio Cassano has been frozen out of the squad all season.
The key to their success so far has been in attack with Fabio Quagliarella and Luis Muriel supported by Bruno Fernandes.
Lazio need a boost after the Derby della Capitale defeat to city rivals Roma and the tension that followed, including controversy over the Kevin Strootman ban that was later revoked.
Because of that incident, Danilo Cataldi is suspended, as he was sent off from the bench.
Keita Balde Diao is in the squad, but a knee injury means he’s only fit for the bench, while Luis Alberto and Patric miss out.
That means Senad Lulic is pushed up to complete the trident attack with Felipe Anderson and Ciro Immobile.
Until last April’s 2-1 victory, Sampdoria had gone eight matches without a win against Lazio in Serie A, picking up just two 1-1 draws.
Sampdoria: Puggioni; Pereira, Silvestre, Skriniar, Regini; Linetty, Torreira, Barreto; Fernandes; Quaglierella, Muriel
Sampdoria bench: Tozzo, Krapikas, Eramo, Dodò, Alvarez, Schick, Krajnc, Palombo, Praet, Cigarini, Djuricic, Budimir
Lazio: Marchetti; Basta, De Vrij, Wallace, Radu; Parolo, Biglia, Milinkovic-Savic; Felipe Anderson, Immobile, Lulic
Lazio bench: Strakosha, Vargic, Bastos, Hoedt, Lukaku, Leitner, Murgia, Kishna, Lombardi, Djordjevic, Keita