Mauro Icardi and Eder visit their old club Sampdoria, but Frank de Boer makes more changes to his Inter side.
It kicks off at 19.45 GMT, follow the build-up and action on the LIVEBLOG.
Even though they beat Torino 2-1 on Wednesday evening, reports continue to suggest the Inter Coach is hanging by a thread with the likes of Leonardo and Laurent Blanc waiting in the wings.
Mauro Icardi and Eder visit their old club Sampdoria, but Frank de Boer makes more changes to his Inter side.
It kicks off at 19.45 GMT, follow the build-up and action on the LIVEBLOG.
Even though they beat Torino 2-1 on Wednesday evening, reports continue to suggest the Inter Coach is hanging by a thread with the likes of Leonardo and Laurent Blanc waiting in the wings.
The midweek result ended a run of three consecutive Serie A defeats, but the performance was still not entirely convincing.
Icardi and Eder are chosen to lead the line in their old hunting ground, as both are ex-Sampdoria strikers, joined by Antonio Candreva.
Ivan Perisic is pushed to the bench, while Geoffrey Kondogbia and Stevan Jovetic are injured, Gary Medel suspended.
It means Marcelo Brozovic starts yet again after being frozen out for a month and partners Joao Mario.
Curiously, Gabriel ‘Gabigol’ Barbosa was not called up for the trip and it seems to be a tactical choice to leave out the €29.5m signing from Santos.
Davide Santon returns in place of Yuto Nagatomo despite his howler to give away a last-gasp penalty for Atalanta.
Sampdoria won the Derby della Lanterna with Genoa last week and rested most of their star names for the trip to Juventus, so Fabio Quagliarella and Colombia international Luis Muriel will be fresh.
Bruno Fernandes gets the nod in the trequartista role rather than ex-Inter flop Ricky Alvarez, while Dennis Praet is not fit enough to start.
Emiliano Viviano, Angelo Palombo, Carlos Carbonero and Daniel Pavlovic are still injured.
Sampdoria: Puggioni; Sala, Silvestre, Skriniar, Regini; Barreto, Torreira, Linetty; Bruno Fernandes; Quagliarella, Muriel
Sampdoria bench: Krapikas, Tozzo, Amuzie, Eramo, Alvarez, Pereira, Schick, Krajnc, Praet, Cigarini, Djuricic, Budimir
Inter: Handanovic; Ansaldi, Miranda, Murillo, Santon; Brozovic, Joao Mario, Banega; Candreva, Icardi, Eder
Inter bench: Carrizo, Andreolli, Palacio, Biabiany, Ranocchia, Gnoukouri, D’Ambrosio, Perisic, Nagatomo, Miangue