Roma are decimated by injuries, but start Edin Dzeko, Henrikh Mkhitaryan and Lorenzo Pellegrini together and change to a Jose Mourinho-esque system against Manchester United in the Europa League semi-final.
It kicks off at 20.00 UK time (19.00 GMT), you can follow the build-up and action as it happens on the LIVEBLOG.
Roma are decimated by injuries, but start Edin Dzeko, Henrikh Mkhitaryan and Lorenzo Pellegrini together and change to a Jose Mourinho-esque system against Manchester United in the Europa League semi-final.
It kicks off at 20.00 UK time (19.00 GMT), you can follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi had been leading the first leg 2-1, but collapsed after the break for a 6-2 defeat at Old Trafford.
It means they would have to win 4-0 here to reach the Final.
As if that weren’t hard enough, they also have even more injuries, losing Jordan Veretout, Leonardo Spinazzola and Pau Lopez in the first half of that game, leaving them with no substitution slots.
Gianluca Mancini returns from suspension, but Gonzalo Villar, Amadou Diawara, Carles Perez, Stephan El Shaarawy, Riccardo Calafiori and Nicolò Zaniolo are also out of action.
There are precious few left to choose from, so Paulo Fonseca – in one of his last games before Jose Mourinho takes over next season – transforms the 3-4-2-1 line-up to what seems to be a 4-2-3-1.
This has Lorenzo Pellegrini in a trequartista role flanked by Pedro and Mkhitaryan supporting Dzeko.
The shortage is in midfield, where Bryan Cristante and Mancini are pushed up to fill the gaps.
There had also been suggestions Antonio Mirante was not fully fit, but he is in the starting XI.
Manchester United are practically full strength, missing only Daniel James, Phil Jones and Anthony Martial.
Edinson Cavani, Paul Pogba and Bruno Fernandes are all former Serie A players who start, as Ole Gunnar Solskjaer doesn’t rotate the squad, sticking to a largely first choice side.
Roma: Mirante; Karsdorp, Smalling, Ibanez, Peres; Cristante, Mancini; Pedro, Pellegrini, Mkhitaryan; Dzeko
Roma bench: Boer, Fuzato, Santon, Mayoral, Kumbulla, Bove, Ciervo, Darboe, Zalewski
Man Utd: De Gea; Wan-Bissaka, Bailly, Maguire, Shaw; van de Beek, Fred; Greenwood, Bruno Fernandes, Pogba; Cavani
Man Utd bench: Grant, Henderson, Lindelof, Mata, Rashford, Diallo, Alex Telles, Matic, B Williams, Tuanzebe, McTominay, Elanga
Ref: Brych (GER)