Roma start Cengiz Under, Henrikh Mkhitaryan and Edin Dzeko as they host on-form Lecce with Antonin Barak and Gianluca Lapadula.
It kicks off at the Stadio Olimpico in Rome at 17.00 GMT.
You can follow the build-up and action as it happens on the LIVEBLOG.
Roma start Cengiz Under, Henrikh Mkhitaryan and Edin Dzeko as they host on-form Lecce with Antonin Barak and Gianluca Lapadula.
It kicks off at the Stadio Olimpico in Rome at 17.00 GMT.
You can follow the build-up and action as it happens on the LIVEBLOG.
This is one of only two Serie A games going ahead today, as Torino-Parma, Atalanta–Sassuolo, Verona–Cagliari and Inter–Sampdoria have all been called off due to the outbreak of the Coronavirus.
Paulo Fonseca’s men played a hard-fought 1-0 win over KAA Gent on Thursday evening in the Europa League, with Carles Perez scoring the only goal.
Perez is on the bench this time, as Cengiz Under, Lorenzo Pellegrini and Mkhitaryan fan out behind Dzeko, with Bruno Peres, Gianluca Mancini and Aleksandar Kolarov chosen in defence.
Amadou Diawara, Javier Pastore, Nicolò Zaniolo, Davide Zappacosta, Antonio Mirante and Juan Jesus are out injured.
While Roma are stuttering going into this game with three consecutive Serie A defeats, Lecce are on a roll of three wins on the bounce that took them away from the relegation zone.
Coach Fabio Liverani seems to have found his formation with the January signings, although Riccardo Saponara didn’t make this trip along with Filippo Falco, Diego Farias and Khouma Babacar.
It means Antonin Barak is moved into a more advanced role alongside Marco Mancosu to support Gianluca Lapadula.
Gabriel is still not 100 per cent fit, so Mauro Vigorito is confirmed in goal.
There was an ugly incident for Lecce ultras on their way up to Rome for this game, as they were ambushed by local rivals from Bari in a motorway service station.
Along with a brawl in the road, their bus was set on fire, meaning they could not continue the journey.
Roma: Pau Lopez; Bruno Peres, Smalling, Mancini, Kolarov; Veretout, Cristante; Under, Pellegrini, Mkhitaryan, Dzeko
Roma bench: Fuzato, Cardinali, Cetin, Santon, Fazio, Spinazzola, Ibanez, Perotti, Perez, Kluivert, Kalinic
Lecce: Vigorito; Donati, Lucioni, Rossettini, Calderoni; Petriccione, Deiola, Majer; Mancosu, Barak; Lapadula
Lecce bench: Gabriel, Chironi, Rispoli, Meccariello, Dell’Orco, Paz, Vera, Tachtsidis, Maselli, Oltremarini, Shakhov, Rimoli
Ref: Giacomelli