Borja Mayoral, Carles Perez and Bryan Reynolds start for Roma, who miss Leonardo Spinazzola among others, while Bologna have Rodrigo Palacio back.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
Borja Mayoral, Carles Perez and Bryan Reynolds start for Roma, who miss Leonardo Spinazzola among others, while Bologna have Rodrigo Palacio back.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
The Giallorossi are flying high in the Europa League after winning 2-1 away to Ajax in Thursday’s quarter-final first leg, but that also means fatigue and the need for squad rotation.
It’s not easy for Paulo Fonseca, because Spinazzola joined Chris Smalling, Stephan El Shaarawy, Marash Kumbulla, Juan Jesus and Nicolò Zaniolo on the treatment table.
The good news is that Henrikh Mkhitaryan is back on the bench after a long lay-off.
Mayoral leads the way with Carles Perez and Pedro, while Bruno Peres steps in for Spinazzola.
There are surprises too, Antonio Mirante and Bryan Reynolds getting rare starts.
Bologna make the trip without Gary Medel, Takehiro Tomiyasu, Aaron Hickey, Federico Santander and Paolo Faragò.
Rodrigo Palacio was suspended for the 1-0 defeat to Inter last week, but he returns and takes the centre-forward role, moving Musa Barrow into support.
Above all, Lukasz Skorupski has shaken off COVID and returns to the goal.
Roma: Mirante; Mancini, Fazio, Ibanez; Reynolds, Villar, Diawara, Bruno Peres; Perez, Pedro; Borja Mayoral
Bologna: Skorupski; De Silvestri, Danilo, Soumaoro, Dijks; Schouten, Svanberg; Skov Olsen, Soriano, Barrow; Palacio
Ref: Guida