Duvan Zapata, Josip Ilicic and Ruslan Malinovskyi take on Edin Dzeko, Henrikh Mkhitaryan and Lorenzo Pellegrini, as Atalanta visit Roma with an eye on second place.
It kicks off at the Stadio Olimpico at 17.30 UK time (16.30 GMT).
You can follow all the build-up and action as it happens from this game and Napoli–Lazio on the LIVEBLOG.
Duvan Zapata, Josip Ilicic and Ruslan Malinovskyi take on Edin Dzeko, Henrikh Mkhitaryan and Lorenzo Pellegrini, as Atalanta visit Roma with an eye on second place.
It kicks off at the Stadio Olimpico at 17.30 UK time (16.30 GMT).
This is a huge opportunity for La Dea, because after Milan lost 2-1 to Sassuolo, a win would catapult them into second place.
It comes after beating Juventus 1-0 at the weekend allowed them to fly into third, so would be a double climb in just four days.
Hans Hateboer is the only absentee, as Cristian Romero returns from suspension to bolster the defence.
Malinovskyi steps back in too after he was rested on Sunday, with Josip Ilicic getting an increasingly rare start in support of Duvan Zapata.
This allows them to have Luis Muriel come off the bench against tired legs.
Roma are certainly tired, because the strain of reaching the Europa League semi-final has taken its toll with mounting muscular injuries.
Pedro Rodriguez is the latest, ruled out for 10 days, joining Leonardo Spinazzola, Chris Smalling, Marash Kumbulla, Stephan El Shaarawy and long-term absentee Nicolò Zaniolo.
Amadou Diawara also sits out a ban, further limiting the midfield options.
Lorenzo Pellegrini does return from suspension, with Mkhitaryan getting back to full fitness and Dzeko rotating with Borja Mayoral.
They are in seventh place, already at least 10 points off fourth, and know their most likely route to the Champions League is to win the Europa League.
Atalanta have a remarkable record against Roma, losing just one of their last 12 Serie A meetings, winning six of them.
Roma: Pau Lopez; Mancini, Cristante, Ibanez; Karsdorp, Villar, Veretout, Calafiori; Pellegrini, Mkhitaryan; Dzeko
Atalanta: Gollini; Djimsiti, Romero, Palomino; Mahle, De Roon, Freuler, Gosens; Ilicic, Malinovskyi; Duvan Zapata
Ref: Calvarese