Roma and Sassuolo are surprisingly tied in second place going into the Stadio Olimpico, as Francesco Totti and Miralem Pjanic start.
It kicks off at 14.00 UK time (13.00 GMT), follow all the action from every Serie A game on our LIVEBLOG.
The Giallorossi did well to hold Barcelona 1-1 here in the Champions League on Wednesday with a sensational Alessandro Florenzi strike from 55 metres out.
Roma and Sassuolo are surprisingly tied in second place going into the Stadio Olimpico, as Francesco Totti and Miralem Pjanic start.
It kicks off at 14.00 UK time (13.00 GMT), follow all the action from every Serie A game on our LIVEBLOG.
The Giallorossi did well to hold Barcelona 1-1 here in the Champions League on Wednesday with a sensational Alessandro Florenzi strike from 55 metres out.
It’s all change for Rudi Garcia, as captain Totti returns to the starting XI with Mohamed Salah and Juan Manuel Iturbe, while Morgan De Sanctis steps in for the injured Wojciech Szczesny.
Pjanic is also back and thrown straight into the mix after recovering much earlier than expected from injury.
Sassuolo are unbeaten with seven points from three games and their Coach, ex-Roma player Eusebio Di Francesco, knows the Olimpico well.
Sime Vrsaljko is suspended, while Luca Antei is injured and Domenico Berardi only fit for the bench.
Antonio Floro Flores, Gregoire Defrel and Matteo Politano form the trident attack.
This fixture was only played twice in Serie A and both times ended with a share of the spoils.
Roma: De Sanctis; Maicon, Manolas, Rudiger, Torosidis; Pjanic, De Rossi, Nainggolan; Salah, Totti, Iturbe
Sassuolo: Consigli; Gazzola, Cannavaro, Acerbi, Peluso; Missiroli, Magnanelli, Duncan; Politano, Defrel, Floro Flores