Roma need a victory over giant-killers CSKA Moscow and must rely on Edin Dzeko with Cengiz Under, Lorenzo Pellegrini and Stephan El Shaarawy.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
Follow the build-up and action as it happens from this game and Manchester United-Juventus on the LIVEBLOG.
Roma need a victory over giant-killers CSKA Moscow and must rely on Edin Dzeko with Cengiz Under, Lorenzo Pellegrini and Stephan El Shaarawy.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
The Giallorossi are back in crisis mode after a shock 2-0 home defeat to SPAL on Saturday, a result that made the previous four straight wins in all competition seemingly futile.
Coach Eusebio Di Francesco stands by the 4-2-3-1 system with Lorenzo Pellegrini in a more advanced trequartista role, again flanked by Cengiz Under and El Shaarawy.
Justin Kluivert had been tipped to feature, but isn’t even in the squad due to a muscular problem.
Aleksandar Kolarov is still unavailable due to a fractured toe, so Davide Santon steps in, while Kostas Manolas and Daniele De Rossi return from injury.
Javier Pastore, Diego Perotti and Rick Karsdorp are unavailable.
CSKA Moscow caused a huge upset in this group by beating reigning Champions League holders Real Madrid 1-0.
They too have a lengthy absentee list, including suspended veteran goalkeeper Igor Akinfeev.
Out injured are Kristijan Bistrovic, Abel Hernandez, Konstantin Kuchaev, Makarov, Georgi Schennikov and Viktor Vasin.
These teams have met four times before, home and away in the second round of the 1991-92 Cup Winners’ Cup and again in the 2014-15 Champions League group phase.
Roma are unbeaten in seven Champions League home games, winning their last six.
Roma: Olsen; Florenzi, Manolas, Fazio, Santon; De Rossi, Nzonzi; Under, Lorenzo Pellegrini, El Shaarawy; Dzeko
Roma bench: Mirante, Cristante, Juan Jesus, Kolarov, Schick, Marcano, Zaniolo
CSKA Moscow: Pomazun; Mario Fernandes, Chernov, Rodrigo Becao, Magnusson, Nababhkin; Oblyakov, Akhmetov, Sigurdsson; Vlasic; Chalov
CSKA bench: Kyrnats, Dzagoev, Efremov, Nishimura, Gordyushenko, Zhamaletdinov, Khosonov
Ref: Sidiropoulos (GRE)