Victor Osimhen, Chucky Lozano and Lorenzo Insigne lead Napoli out against an Udinese side with Rodrigo De Paul and Roberto Pereyra.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Diego Armando Maradona.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Partenopei are in fourth place and only two behind Milan and Atalanta in joint second, having leapfrogged Juventus at the weekend.
Victor Osimhen, Chucky Lozano and Lorenzo Insigne lead Napoli out against an Udinese side with Rodrigo De Paul and Roberto Pereyra.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Diego Armando Maradona.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Partenopei are in fourth place and only two behind Milan and Atalanta in joint second, having leapfrogged Juventus at the weekend.
However, Gennaro Gattuso’s men were held here by Cagliari 10 days ago and cannot afford to be complacent.
Kalidou Koulibaly, Nikola Maksimovic, Faouzi Ghoulam and Stanislav Lobotka are out of action, so Amir Rrahmani again partners Kostas Manolas in defence.
Osimhen leads the attack with Lozano, Insigne and Piotr Zielinski, giving Matteo Politano a rest.
Udinese are practically safe from the threat of relegation, which is just as well, because they have Tolgay Arslan, Gerard Deulofeu, Ilija Nestorovski, Ignacio Pussetto and Jayden Braaf injured.
De Paul has been linked with a move to Napoli this summer, as well as Juventus, Inter, Milan and Leeds United.
He pulls the strings behind Roberto Pereyra and Stefano Okaka.
Napoli: Meret; Di Lorenzo, Manolas, Rrahmani, Hysaj; Fabian Ruiz, Bakayoko; Lozano, Zielinski, L Insigne; Osimhen
Udinese: Musso; Becao, Bonifazi, Zeegelaar; N Molina, De Paul, Walace, Makengo, Stryger-Larsen; Pereyra; Okaka
Ref: Calvarese