Napoli need a point against KRC Genk to secure their Champions League Round of 16 qualification, so Arkadiusz Milik returns with Lorenzo Insigne dropped.
It kicks off at the Stadio San Paolo at 17.55 GMT.
You can follow all the build-up and action as it happens from this game and then Inter-Barcelona on the LIVEBLOG.
Napoli need a point against KRC Genk to secure their Champions League Round of 16 qualification, so Arkadiusz Milik returns with Lorenzo Insigne dropped.
It kicks off at the Stadio San Paolo at 17.55 GMT.
You can follow all the build-up and action as it happens from this game and then Inter-Barcelona on the LIVEBLOG.
The Partenopei are in crisis, on a nine-match winless streak in all competition and with growing reports Carlo Ancelotti will be dismissed regardless of today’s result.
Players are also taking legal advice against the club following their mutiny against a training retreat and consequent fines from the club.
When it comes to team news, Arek Milik returns from his injury and Dries Mertens is preferred to Hirving Lozano.
Captain Insigne is also dropped in favour of Fabian Ruiz, who is moved over to the left flank.
Kevin Malcuit, Faouzi Ghoulam and Nikola Maksimovic are all out injured.
Genk are already sure of their status at the bottom of this Champions League group, as they have only one point from five games and that was a 0-0 home draw with Napoli.
They fired coach Felice Mazzù on November 12 and brought in Hannes Wolf.
Carlos Cuesta and Jere Uronen are out injured, limiting their options in defence, but Ally Mbwana Samatta is the one to watch, as he scored three goals in five Champions League games this season. It will be his 27th birthday on Friday.
Midfielder Sander Berge is the most valuable player and has already been linked with several clubs, including Napoli.
Maarten Vandevoordt makes history as the youngest goalkeeper ever in the Champions League, aged just 17 years, nine months and 10 days.
The last Belgian side to visit Napoli was Club Brugge, losing 5-0 in the Europa League in September 2015.
Napoli are unbeaten at home in the Champions League since Manchester City’s 4-2 result in November 2017, managing four wins and two draws.
We could see Napoli finish the Champions League group phase unbeaten for the first time ever.
They will qualify with at least a draw, but could even afford to lose and go through if RB Salzburg don’t beat Liverpool.
Napoli: Meret; Di Lorenzo, Manolas, Koulibaly, Mario Rui; Callejon, Allan, Zielinski, Fabian Ruiz; Mertens, Milik
Napoli bench: Ospina, Luperto, Elmas, Gaetano, Insigne, Llorente, Lozano
Genk: Vandevoordt; Maehle, Dewaest, Lucumí, De Norre; Hrosovsky, Berge, Ito; Paintsil, Onuachu, Samatta
Genk bench: Coucke, Wouters, Neto Borges, Odey, Hagi, Bongonda, Ndongala
Ref: Cakir (TUR)