Carlo Ancelotti shakes up Napoli with Simone Verdi, Kevin Malcuit, Marko Rog, Adam Ounas and Dries Mertens against a Sassuolo side fighting for second place.
It kicks off at the Stadio San Paolo at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action from today’s six Serie A games on the LIVEBLOG.
Carlo Ancelotti shakes up Napoli with Simone Verdi, Kevin Malcuit, Marko Rog, Adam Ounas and Dries Mertens against a Sassuolo side fighting for second place.
It kicks off at the Stadio San Paolo at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action from today’s six Serie A games on the LIVEBLOG.
The Partenopei are right back on track with their midweek 1-0 Champions League victory over Liverpool, decided by a late Lorenzo Insigne strike.
They need to replicate that form in Serie A, having fallen temporarily six points adrift of leaders Juventus.
Ancelotti continues his squad rotation, bringing in Verdi, Mertens, full-back Malcuit, midfielders Amadou Diawara, Rog and Ounas.
Mario Rui is suspended after his red card against Juve, while natural replacement Sebastiano Luperto is out injured.
Marek Hamsik, Lorenzo Insigne and Jose Callejon are unusually on the bench.
Sassuolo have lost only two games this season, to Juventus and Milan, as Coach Roberto De Zerbi – a former Napoli striker – has taken them to some impressive results, including a victory over Inter.
The 4-1 loss to Milan last week was surprising and Kevin-Prince Boateng leads the attack with Filip Djuricic, Chelsea-owned Jeremie Boga and no Domenico Berardi.
Napoli: Ospina; Hysaj, Koulibaly, Albiol, Malcuit; Rog, Diawara, Zielinski, Ounas; Mertens, Verdi
Sassuolo: Consigli; Marlon, Magnani, Ferrari; Lirola, Magnanelli, Locatelli, Rogerio; Djuricic, Boateng, Boga