David Ospina gets his Napoli debut with Arkadiusz Milik, as Gonzalo Higuain leads the way with Fabio Borini for Milan at his old hunting ground.
It kicks off at the Stadio San Paolo at 19.30 UK time (18.30 GMT).
Follow the build-up and action as it happens while giving your views on the LIVEBLOG.
David Ospina gets his Napoli debut with Arkadiusz Milik, as Gonzalo Higuain leads the way with Fabio Borini for Milan at his old hunting ground.
It kicks off at the Stadio San Paolo at 19.30 UK time (18.30 GMT).
Follow the build-up and action as it happens while giving your views on the LIVEBLOG.
It is a reunion for Carlo Ancelotti with his beloved Milan and former midfielder Gennaro Gattuso, while Higuain and Pepe Reina return to face their old fans.
Reina is on the bench, so native Neapolitan Gianluigi Donnarumma takes the Rossoneri gloves.
There were doubts over who would start in goal for Napoli this evening, as Alex Meret is injured, while Orestis Karnezis played the 2-1 win away to Lazio.
David Ospina arrived on loan from Arsenal on transfer deadline day and is given his debut this evening.
Fabian Ruiz is on the treatment table with Faouzi Ghoulam and Amin Younes, while Arkadiusz Milik is again chosen rather than Dries Mertens to lead the attack.
Milan make their competitive debut, as the Week 1 fixture with Genoa was postponed to October 31 due to the Ponte Morandi tragedy.
It means Gonzalo Higuain gets his first match in very familiar surroundings, but Hakan Calhanoglu is suspended.
Suso and Fabio Borini are chosen to flank Pipita, with Jack Bonaventura in midfield, while Mateo Musacchio is chosen to partner new captain Alessio Romagnoli rather than summer signing Mattia Caldara.
Tiemoue Bakayoko is also on the bench after his loan with option to buy move from Chelsea.
Napoli: Ospina; Hysaj, Albiol, Koulibaly, Mario Rui; Allan, Hamsik; Zielinski; Callejon, Milik, Insigne
Napoli bench: Marfella, Karnezis, Malcuit, Verdi, Ounas, Luperto, Mertens, Maksimovic, Chiriches, Rog, Diawara
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Biglia, Bonaventura; Suso, Higuain, Borini
Milan bench: Reina, A Donnarumma, Mauri, Castillejo, Bakayoko, Bertolacci, Abate, Caldara, Simic, Cutrone, Halilovic, Laxalt