Napoli and Inter are doing battle for the Scudetto, but face off tonight in the Coppa Italia quarter-final.
It kicks off at the Stadio San Paolo at 19.45 GMT and passage to the semis will be decided tonight after 90 minutes, extra time or even penalties.
The winner goes on to face either Juventus or Lazio in the next round.
The Partenopei are top of the table and lost only one competitive match since August, so on current form would be considered the favourites.
Napoli and Inter are doing battle for the Scudetto, but face off tonight in the Coppa Italia quarter-final.
It kicks off at the Stadio San Paolo at 19.45 GMT and passage to the semis will be decided tonight after 90 minutes, extra time or even penalties.
The winner goes on to face either Juventus or Lazio in the next round.
The Partenopei are top of the table and lost only one competitive match since August, so on current form would be considered the favourites.
Maurizio Sarri rotates his squad, resting Gonzalo Higuain, Lorenzo Insigne, Marek Hamsik and Jorginho.
Dries Mertens gets his chance to shine against the club that tried to sign him over the summer and the same goes for Manolo Gabbiadini.
Although his three-match ban for violent conduct only applies to Serie A football, Felipe Melo is left on the Inter bench.
Instead, Roberto Mancini adopts a 4-2-3-1 system with Jonathan Biabiany, Adem Ljajic and Ivan Perisic fanning out behind Stevan Jovetic.
Samir Handanovic keeps his spot following headline-making miracles in the 1-1 draw at Atalanta on Saturday, while Mauro Icardi is sent to the bench.
When these sides met here in Serie A earlier this season, it ended 2-1 to Napoli, but 10-man Inter hit the woodwork deep into stoppages and forced a desperate Pepe Reina fingertip save.
Napoli lost to Lazio in the Coppa Italia semi-final last season, while Inter haven’t reached the semis since 2012-13.
Napoli: Reina; Hysaj, Chiriches, Koulibaly, Strinic; Allan, Valdifiori, David Lopez; Callejon, Gabbiadini, Mertens
Napoli bench: Rafael, Gabriel, Jorginho, Higuain, Maggio, Hamsik, Deli, Insigne, Ghoulam, Albiol, El Kaddouri, Luperto
Inter: Handanovic; Nagatomo, Miranda, Juan Jesus, Telles; Medel, Kondogbia; Biabiany, Ljajic, Perisic; Jovetic
Inter bench: Carrizo, Palacio, Icardi, Montoya, Santon, Ranocchia, Murillo, Gnoukouri, D’Ambrosio, Brozovic, Melo, Manaj