Napoli ring the changes again with struggling Empoli, using Lorenzo Insigne and Dries Mertens together with Fabian Ruiz and Marko Rog.
It kicks off at the Stadio San Paolo at 19.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
Carlo Ancelotti rests several big names ahead of the Champions League showdown with Paris Saint-Germain, including Arkadiusz Milik, Raul Albiol, Marek Hamsik and Jose Callejon.
Napoli ring the changes again with struggling Empoli, using Lorenzo Insigne and Dries Mertens together with Fabian Ruiz and Marko Rog.
It kicks off at the Stadio San Paolo at 19.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
Carlo Ancelotti rests several big names ahead of the Champions League showdown with Paris Saint-Germain, including Arkadiusz Milik, Raul Albiol, Marek Hamsik and Jose Callejon.
Instead, Piotr Zielinski, Marko Rog and Amadou Diawara get the nod with Mertens and Insigne forming the partnership in attack, despite strong reports the Italian would be rested.
David Ospina is given the night off in favour of Orestis Karnezis.
Empoli are without a victory since the opening weekend, but Aurelio Andreazzoli’s style of football has nonetheless impressed many in Serie A.
Ismael Bennacer starts and Miha Zajc has not passed a fitness test, so ex-Roma man Salih Ucan gets the nod instead.
Rade Krunic is a known transfer target for Napoli, as confirmed by Empoli.
Levan Mchedlidze, Lorenzo Lollo and Alejandro Rodriguez remain long-term injury absentees.
Napoli are unbeaten in 11 competitive home matches, winning nine, and have scored in each of the last 20 games played at the San Paolo.
Empoli have only won one of their seven top flight trips to Naples, a 3-1 result in February 2008, along with a draw and five defeats.
The last four editions of this fixture have seen a total of 16 goals.
Napoli: Karnezis; Hysaj, Maksimovic, Koulibaly, Malcuit; Rog, Diawara, Fabian, Zielinski; Insigne, Mertens
Napoli bench: Ospina, D’Andrea, Albiol, Ghoulam, Mario Rui, Allan, Hamsik, Callejon, Milik, Ounas
Empoli: Provedel; Di Lorenzo, Silvestre, Maietta, Antonelli; Acquah, Bennacer, Traore; Krunic, Ucan; Caputo
Empoli bench: Terracciano, Fulignati, Brighi, Veseli, Zajc, La Gumina, Pasqual, Untersee, Capezzi, Marcjanik, Rasmussen, Mraz