Milan look to Derby della Madonnina newcomers Lucas Paqueta and Krzysztof Piatek, while Marcelo Brozovic passes an Inter fitness test.
It kicks off at a packed out San Siro at 19.30 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri go into this showdown in third place, only one point ahead of their city rivals, so it is more than just local pride that is at stake.
Milan look to Derby della Madonnina newcomers Lucas Paqueta and Krzysztof Piatek, while Marcelo Brozovic passes an Inter fitness test.
It kicks off at a packed out San Siro at 19.30 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri go into this showdown in third place, only one point ahead of their city rivals, so it is more than just local pride that is at stake.
Gennaro Gattuso now has practically a full squad at his disposal, other than Giacomo Bonaventura and dropped Riccardo Montolivo, as Mattia Caldara and Cristian Zapata have also recovered from long-term lay-offs.
The only real doubt in the line-up was in midfield, between Lucas Biglia and Tiemoue Bakayoko, but the Chelsea-owned figure got the nod.
Paqueta continues his trend of starting every competitive game since arriving in January, while Piatek is flanked by Suso and Hakan Calhanoglu.
Inter also adopt a 4-3-3 system, but Luciano Spalletti has many problems to deal with, as Radja Nainggolan, Joao Mario, Mauro Icardi and Joao Miranda are out of action.
Brozovic passed a fitness test and is in the starting XI with Roberto Gagliardini and Matias Vecino.
Matteo Politano and Ivan Perisic flank Lautaro Martinez, who missed Thursday’s Europa League defeat to Eintracht Frankfurt as he was suspended.
The Icardi situation has cast a shadow over the Nerazzurri squad, as he has been given the all-clear from medical staff, but insists he feels pain in his knee and will not train with the rest of the team.
This has dragged on since he was stripped of the captaincy on February 13.
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Bakayoko, Paqueta; Suso, Piatek, Calhanoglu
Milan bench: Reina, A Donnarumma, Castillejo, Borini, Conti, Bertolacci, Zapata, Abate, Biglia, Caldara, Cutrone, Laxalt
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Brozovic, Gagliardini; Politano, Lautaro Martinez, Perisic
Inter bench: Padelli, Keita, Ranocchia, Borja Valero, Cedric, Dalbert, Candreva