Roma seek precious points at San Siro, but Mattia Destro and Milan have their pride at stake.
It kicks off at 19.45 UK time (18.45 GMT), follow the action as it happens on our LIVEBLOG.
The battle for second place continues after Roma took it back off Lazio last week, but this round provides a Tale of Two Cities.
While we have Milan v Roma here, tomorrow night is Lazio v Inter.
Roma seek precious points at San Siro, but Mattia Destro and Milan have their pride at stake.
It kicks off at 19.45 UK time (18.45 GMT), follow the action as it happens on our LIVEBLOG.
The battle for second place continues after Roma took it back off Lazio last week, but this round provides a Tale of Two Cities.
While we have Milan v Roma here, tomorrow night is Lazio v Inter.
Of the four sides, the Rossoneri are comfortably worse off and have no chance of European qualification after three consecutive defeats.
The club announced it will stick with Coach Pippo Inzaghi to the end of the season, primarily because a change would make no difference at this stage.
Destro and Philippe Mexes face their past, but another ex-Roma player Jeremy Menez is suspended along with Mattia De Sciglio.
The injury list includes Alessio Cerci, Riccardo Montolivo and Michael Essien.
Milan will unveil their new home strip for the 2015-16 season tonight.
Roma are without Douglas Maicon, Leandro Castan and Kevin Strootman, but confidence is boosted after two wins on the bounce.
Seydou Doumbia flopped in his first few months at Roma, but has now scored two goals in as many games.
The Ivorian again starts in a trident with Gervinho and Victor Ibarbo.
Milan: Diego Lopez; Abate, Alex, Paletta, Antonelli; Poli, De Jong, Van Ginkel; Honda, Destro, Bonaventura
Milan bench: Abbiati, Gori, Mexes, Bocchetti, Zapata, Bonera, Suso, Mastalli, Felicioli, Modic, Mastour, Pazzini
Roma: De Sanctis; Florenzi, Manolas, Astori, Torosodis; Nainggolan, De Rossi, Pjanic; Ibarbo, Doumbia, Gervinho
Roma bench: Skoropuski, Balzaretti, Holebas, A.Cole, Yanga Mbiwa, Keita, Paredes, Uçan, Iturbe, Ljajic, Sanabria, Totti