Mattia Destro and Salvatore Bocchetti make their Milan debuts from the start against Parma.
It kicks off at San Siro at 19.45 GMT, click here for a match preview.
The Rossoneri are wasting no time and throw new signings Destro and Bocchetti straight into the starting XI.
Pippo Inzaghi already survived the axe once this week after losing 1-0 to 10-man Lazio in the Coppa Italia quarter-final.
Mattia Destro and Salvatore Bocchetti make their Milan debuts from the start against Parma.
It kicks off at San Siro at 19.45 GMT, click here for a match preview.
The Rossoneri are wasting no time and throw new signings Destro and Bocchetti straight into the starting XI.
Pippo Inzaghi already survived the axe once this week after losing 1-0 to 10-man Lazio in the Coppa Italia quarter-final.
His team are without a Serie A victory in 2015 and are sliding rapidly down the standings.
If Milan fail to beat bottom of the table Parma, then it will be considered a catastrophic result.
The Ducali look doomed after defeat to Cesena and Antonio Cassano terminated his contract by mutual consent due to six months of unpaid wages.
Other players may well follow his lead and it remains to be seen whether Parma will still exist next season.
Coach Roberto Donadoni said it “requires more dignity to stay in the saddle than to run away” and called Cassano’s actions “cowardly.”
The situation is dire, but his speech may well have worked, as midweek Parma forced Juventus to the 89th minute in the Coppa Italia quarter-final, eventually losing to an Alvaro Morata strike.
Milan have numerous absentees, as Philippe Mexes begins a four-match ban for putting Stefano Mauri in a choke-hold.
Stephan El Shaarawy, Riccardo Montolivo, Nigel de Jong, Ignazio Abate, Cristian Zapata, Giacomo Bonaventura, Mattia De Sciglio and Daniele Bonera are all injured.
Parma miss Dias Felipe, Jonathan Biabiany, Cristobal Jorquera, Abdel Ghezzal, Afriyie Acquah, Ishak Belfodil, Andi Lila, Massimo Coda and Pedro Mendes.
January loans Cristiano Rodriguez and Silvestre Varela start along with Milan-owned midfielder Antonio Nocerino.
When these teams last met in September, Milan won 5-4 at the Stadio Tardini.
Milan: Diego Lopez; Zaccardo, Rami, Alex, Bocchetti; Cerci, Poli, Van Ginkel, Honda; Menez, Destro
Milan bench: Abbiati, Gori, Albertazzi, Calabria, De Santis, Essien, Muntari, Suso, Felicioli, Di Molfetta, Pazzini
Parma: Mirante; Santacroce, Lucarelli, Costa, Galloppa; Gobbi, Nocerino, Mariga; Varela, Palladino, Rodriguez
Parma bench: Bajza, Iacobucci, Cassani, Paletta, Rispoli, Lodi, Mauri, Haraslin, Pozzi