Lazio can build on their Derby della Capitale victory, but are without Luis Alberto and Luiz Felipe against Manuel Locatelli’s Sassuolo.
It kicks off at the Stadio Olimpico at 17.00 GMT.
Lazio can build on their Derby della Capitale victory, but are without Luis Alberto and Luiz Felipe against Manuel Locatelli’s Sassuolo.
It kicks off at the Stadio Olimpico at 17.00 GMT.
The Aquile are brimming with confidence after thrashing their local rivals Roma 3-0 last week and progressing to the Coppa Italia quarter-finals too.
Luis Alberto is out after he was rushed to hospital for an emergency appendectomy, while Luiz Felipe had ankle surgery.
Danilo Cataldi is also on the treatment table, so Pedro steps into defence and Jean-Daniel Akpa Akpro in midfield.
Ciro Immobile and Felipe Caicedo were rested in the Coppa midweek against Parma, but it's Joaquin Correa who partners the Italian.
Sassuolo’s injury crisis is beginning to ease a little, with the return of Manuel Locatelli and Jeremie Boga, but Domenico Berardi and Medhi Bourabia are still out of action.
Vlad Chiriches also sits out a ban, as Gregoire Defrel comes into the trio supporting Ciccio Caputo.
Lazio: Reina; Patric, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Akpa Akpro, Marusic; Correa, Immobile
Sassuolo: Consigli; Muldur, Marlon, Ferrari, Rogerio; Obiang, Locatelli; Defrel, Djuricic, Traore; Caputo
Ref: Giua