Lazio try to get back on track with Ciro Immobile and Joaquin Correa, plus the return of Stefan Radu, but Inter are having the perfect start with Romelu Lukaku, Lautaro Martinez and Achraf Hakimi.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT).
You can follow all the build-up and action as it happens from this game, Benevento-Bologna and Parma-Verona on the LIVEBLOG.
Lazio try to get back on track with Ciro Immobile and Joaquin Correa, plus the return of Stefan Radu, but Inter are having the perfect start with Romelu Lukaku, Lautaro Martinez and Achraf Hakimi.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT).
This was a Scudetto showdown last season and before that a head-to-head for a spot in the Champions League, but so far this term Lazio have stuttered and shown a lack of strength in depth.
The same cannot be said of Inter, as Antonio Conte now practically has two entire teams to rotate and is making the most of it with a thrilling 4-3 win over Fiorentina and 5-2 at Benevento.
Lazio miss Vedat Muriqi, Senad Lulic, Luiz Felipe and Denis Vavro, but Stefan Radu returns from injury to bolster the defence.
Tucu Correa pulled out in the warm-up during last week’s 4-1 home defeat to Atalanta with a back problem, but he too returns with Capocannoniere Immobile.
Inter have a full squad to choose from, save Matias Vecino and Cagliari-bound Radja Nainggolan, so Conte rings the changes yet again.
Hakimi has been a revelation on the right, with Ivan Perisic battling Ashley Young and Aleksandar Kolarov for the left slot.
Arturo Vidal has shaken off a knock to start with Lukaku and Lautaro Martinez.
Lazio: Strakosha; Patric, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Marusic; Correa, Immobile
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Hakimi, Barella, Vidal, Gagliardini, Perisic; R Lukaku, Lautaro Martinez
Ref: Irrati