Lazio need at least a point against Club Brugge to reach the Champions League Last 16, so look to Ciro Immobile and Sergej Milinkovic-Savic.
It kicks off at the Stadio Olimpico at 17.55 GMT, you can follow the build-up and action as it happens from this game and Barcelona-Juventus on the LIVEBLOG.
Lazio need at least a point against Club Brugge to reach the Champions League Last 16, so look to Ciro Immobile and Sergej Milinkovic-Savic.
It kicks off at the Stadio Olimpico at 17.55 GMT, you can follow the build-up and action as it happens from this game and Barcelona-Juventus on the LIVEBLOG.
The Aquile are still unbeaten in the Champions League and a draw would be enough to see them through to the final 16 for the first time since 1999-2000.
In fact, they can still top the group if they win and Borussia Dortmund fail to defeat Zenit, who are guaranteed fourth place.
These sides drew 1-1 in Belgium, an extraordinary achievement considering the squad was decimated by COVID and injuries.
Vedat Muriqi and Patric are the only real absentees for Simone Inzaghi, as Luiz Felipe and Joaquin Correa are able to start, albeit not quite at 100 per cent.
Manuel Lazzari and Adam Marusic get the nod on the wings, sending Mohamed Fares to the bench and re-routing Marusic to the left.
Hitman Immobile leads the way, with Luis Alberto, Milinkovic-Savic and Lucas Leiva in the middle.
Club Brugge need a victory to qualify for the Champions League Round of 16, or drop down into the Europa League.
Defender Matej Mitrovic is on the treatment table with a heel injury, but Brugge are top of the Belgian Pro League and won 3-0 away to Zenit in their last Champions League game.
Charles De Ketelaere is the danger man, having already attracted interest from Milan, with Noa Lang and Krepin Diatta upfront.
Simon Mignolet brings experience in goal, but striker Emmanuel Dennis Bonaventure is on the bench.
Lazio: Reina; Luiz Felipe, Hoedt, Acerbi; Lazzari, Milinkovic, Leiva, Luis Alberto, Marusic; Correa, Immobile
Lazio bench: Strakosha, Alia, Pereira, Anderson, Armini, Parolo, Escalante, Caicedo, Radu, Cataldi, Akpa-Akpro, Fares
Club Brugge: Mignolet; Mata, Kossounou, Ricca, Sobol; Vormer, Vanaken, Balanta; De Ketelaere; Diatta, Lang
Club Brugge bench: Horvath, Schrijvers, Deli, Okereke, Rits, Badji, Van der Brempt, Bonaventure Dennis, Mehele
Ref: Cakir (TUR)