Lazio and Roma are separated by only one point as they face off for second place, Champions League access and bragging rights.
The Derby della Capitale kicks off at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens in our LIVEBLOG.
There’s only one round left after this, as Roma host Palermo and Lazio visit fourth-placed Napoli, so this result could well decide second place.
Lazio and Roma are separated by only one point as they face off for second place, Champions League access and bragging rights.
The Derby della Capitale kicks off at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens in our LIVEBLOG.
There’s only one round left after this, as Roma host Palermo and Lazio visit fourth-placed Napoli, so this result could well decide second place.
Stefano Pioli’s Aquile are without Stefan Radu, Lorik Cana, Ederson and Brayan Perea, but Lucas Biglia has recovered in record time from a knee injury.
Felipe Anderson is the one to watch alongside Stefano Mauri, Antonio Candreva and of course Miroslav Klose in a very attack-minded 4-2-3-1 formation, while Stefan de Vrij is fit again to start in defence.
Roma miss Leandro Castan and Kevin Strootman, though Gervinho and Douglas Maicon return to the bench.
Francesco Totti and Daniele De Rossi have often let the tension of the occasion get to them, as Romans and Romanisti.
They both start along with fellow local boy Alessandro Florenzi, who is back from suspension and returns to a more attacking role after weeks of being a full-back.
Seydou Keita gets the nod ahead of Miralem Pjanic, who has been really struggling lately.
The referee today is Nicola Rizzoli, widely considered to be one of the best officials in the world.
Lazio: Marchetti; Basta, De Vrij, Gentiletti, Lulic; Parolo, Biglia; Candreva, Mauri, Felipe Anderson; Klose
Lazio bench: Berisha, Strakosha, Braafheid, Ciani, Mauricio, Onazi, Cavanda, Ledesma, Pereirinha, Cataldi, Keita, Djordjevic
Roma: De Sanctis; Torosidis, Manolas, Yanga-Mbiwa, Holebas; Keita, De Rossi, Nainggolan; Florenzi, Totti, Iturbe
Roma bench: Skorupski, Maicon, Astori, Cole, Balzaretti, Uçan, Paredes, Pjanic, Gervinho, Ljajic, Ibarbo, Doumbia