Cristiano Ronaldo is again supported by Dejan Kulusevski and Federico Chiesa, but Spezia have top scorer M’Bala Nzola back in the starting XI.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
Juve’s Scudetto hopes are hanging by a thread following the 1-1 draw with Hellas Verona, leaving them 10 points adrift of leaders Inter, albeit with a game in hand.
Cristiano Ronaldo is again supported by Dejan Kulusevski and Federico Chiesa, but Spezia have top scorer M’Bala Nzola back in the starting XI.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
Juve’s Scudetto hopes are hanging by a thread following the 1-1 draw with Hellas Verona, leaving them 10 points adrift of leaders Inter, albeit with a game in hand.
Danilo returns from suspension, but Leonardo Bonucci, Giorgio Chiellini, Juan Cuadrado, Paulo Dybala and Arthur are still out of action.
Alvaro Morata is only fit for the bench after barely training all week due to a viral infection.
Matthijs de Ligt pulled out in the warm-up, so Gianluca Frabotta starts in defence.
However, this time it looks more like a 4-4-2 formation with Dejan Kulusevski and Cristiano Ronaldo upfront, Alex Sandro at left-back, Chiesa and Weston McKennie on the wings.
Spezia have a better record against clubs in the top half of the table than the bottom, including victories over Milan, Napoli and Sassuolo.
Nzola has nine goals in 14 Serie A games this season, but was ruled out by an ankle injury in mid-January and only made his comeback for 20 minutes in the 2-2 draw with Parma.
He gets his first start since January 11, flanked by Emmanuel Gyasi and Diego Farias in a very attack-minded approach.
Riccardo Saponara, Tommaso Pobega, Federico Mattiello and Rafael are still out of action.
Juventus: Szczesny; Danilo, Demiral, Frabotta, Alex Sandro; Chiesa, Bentancur, Rabiot, McKennie; Kulusevski, Ronaldo
Juventus bench: Pinsoglio, Buffon, Ramsey, Morata, Bernardeschi, Di Pardo, Dragusin, Frabotta, Fagioli, Peeters, Ake
Spezia: Provedel; Vignali, Erlic, Terzi, Marchizza; Estevez, Sena, Maggiore; Farias, Nzola, Gyasi
Spezia bench: Zoet, Acampora, Ricci, Galabinov, Agoume, S Bastoni, Salva Ferrer, Chabot, Ismajli, Agudelo, Piccoli
Ref: Sacchi