Italy make changes, including Marco Verratti and Leonardo Bonucci, for their first World Cup qualifier in Israel.
It kicks off at the Sammy Ofer Stadium in Haifa at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
Giampiero Ventura made his debut with a 3-1 friendly defeat to France on Thursday, though this is where he really needs to deliver.
Italy make changes, including Marco Verratti and Leonardo Bonucci, for their first World Cup qualifier in Israel.
It kicks off at the Sammy Ofer Stadium in Haifa at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
Giampiero Ventura made his debut with a 3-1 friendly defeat to France on Thursday, though this is where he really needs to deliver.
Italy are in a very tough group with Spain, Albania, Macedonia, Israel and Lichtenstein, but only the top team go through directly to the 2018 World Cup.
Daniele De Rossi and Andrea Belotti have been ruled out by injury, but Juventus defender Bonucci returns after taking time out to nurse his infant son.
Verratti is in the starting XI after injury forced him to miss Euro 2016, flanked by Giacomo Bonaventura, Antonio Candreva, Marco Parolo and new entry Luca Antonelli.
Eder and Graziano Pellè again form the front two.
Israel have also played only one match under new Coach Elisha Levy, a 3-1 friendly defeat to Serbia.
He seems to be setting his team out in a 4-2-3-1 system with Sheran Yeini an unexpected starter in midfield, having struggled for playing time at Vitesse, while Ben Bitton beats Eli Dasa of Maccabi to a place in defence.
Striker Tomer Hemed is placed as the centre-forward, supported by Brighton & Hove’s Biram Kayal, Tal Ben-Haim and former Palermo man Erin Zahavi.
Eyal Golasa is not in the starting XI, as he has still not fully recovered from a thigh strain.
The referee is 37-year-old Russian Sergej Karasev.
Israel: Goresh; B Bitton, Tzedek, Tibi, Davidzada; N Bitton, Yeini; Kayal, Ben-Chaim, Zahavi; Hemed
Israel bench: Harush, , Kleyman, Dasa, Gershon, Natcho, Dabbur, Einbinder, Magharbeh, Atzily, Saief, Kehat, Golasa
Italy: Buffon; Barzagli, Bonucci, Chiellini; Candreva, Parolo, Verratti, Bonaventura, Antonelli; Eder, Pellè
Italy bench: Donnarumma, Marchetti, De Sciglio, Astori, Ogbonna, Florenzi, Immobile, Montolivo, Pavoletti, Bernardeschi, Gabbiadini, Rugani