Inter make several changes, including Alexis Sanchez replacing Lautaro Martinez and a whole new midfield, while Sassuolo rely on Jeremie Boga, Domenico Berardi and Francesco Caputo.
It kicks off at San Siro behind closed doors at 18.30 UK time (17.30 GMT).
You can follow the build-up and action as it happens from this game, Atalanta–Lazio and Roma–Sampdoria on the LIVEBLOG.
Inter make several changes, including Alexis Sanchez replacing Lautaro Martinez and a whole new midfield, while Sassuolo rely on Jeremie Boga, Domenico Berardi and Francesco Caputo.
It kicks off at San Siro behind closed doors at 18.30 UK time (17.30 GMT).
Antonio Conte has taken the opportunity of the extended break to revamp his tactics and they are working wonders, as Eriksen is relishing his trequartista role behind the strikers.
However, Lautaro Martinez is surprisingly benched in favour of Alexis Sanchez with Romelu Lukaku.
Marcelo Brozovic, Stefano Sensi and Matias Vecino are still out of action, but Borja Valero steps into the midfield with Roberto Gagliardini, while the wing-backs are transformed with Victor Moses and Cristiano Biraghi.
Sunday’s 2-1 win over Sampdoria saw some stunning team goals, but then they fell away after the break and need to keep the intensity going if they’re to genuinely frighten top two Juventus and Lazio.
Sassuolo were hammered 4-1 by Atalanta at the weekend, but the result did not reflect the game, as they wasted numerous scoring opportunities and saw others parried by Pierluigi Gollini.
Marlon is suspended, with Jeremy Toljan joining Filippo Romagna on the treatment table, so coach Roberto De Zerbi has very limited options in defence.
Filip Djuricic replaces Gregoire Defrel in attack, accompanying the old guard Berardi, Boga and Ciccio Caputo.
Sassuolo are unbeaten away to Inter in Serie A since a 7-0 demolition in September 2014, leaving here with three wins and last season’s draw.
Inter: Handanovic; Skriniar, Ranocchia, Bastoni; Moses, Gagliardini, Borja Valero, Biraghi; Eriksen; R Lukaku, Alexis Sanchez
Inter bench: Padelli, Godin, De Vrij, Lautaro Martinez, Young, Asamoah, Barella, Esposito, Pirola, Agoume, D’Ambrosio, Candreva
Sassuolo: Consigli; Muldur, Chiriches, Ferrari, Rogerio; Magnanelli, Obiang; Berardi, Djuricic, Boga; Caputo
Sassuolo bench: Pegolo, Russo, Defrel, Peluso, Raspadori, Traore, Haraslin, Magnani, Piccinini, Bourabia, Locatelli, Kyriakopoulos
Ref: Massa