Inter celebrated their Scudetto triumph last week and are now seeking a 14th consecutive home win, but Sampdoria are the last team to have beaten them in Serie A.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
Inter celebrated their Scudetto triumph last week and are now seeking a 14th consecutive home win, but Sampdoria are the last team to have beaten them in Serie A.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
The Nerazzurri spent the last week partying after securing the title with four rounds to spare, Antonio Conte ending the nine-year Juventus reign that he himself had begun.
There are up to 3,000 fans allowed into a holding pen outside the Stadio Giuseppe Meazza, although it looks as if more have turned up to the party.
Their progress in the second half of the season has been remarkable, as they are unbeaten since that 2-1 result away to Sampdoria on January 6, notching up 14 wins and four draws.
This could also be their 14th consecutive Serie A home victory, having already equalled the all-time club record of 13 set in May 2011.
Conte gives Romelu Lukaku a rare day off, allowing Alexis Sanchez to partner Lautaro Martinez, with Ashley Young, Matias Vecino, Roberto Gagliardini and Andrea Ranocchia among those getting a look-in.
Sampdoria have a full squad to choose from and are fresh from their 2-0 win over Roma.
It’s a return to San Siro for former Inter players Antonio Candreva and Keita Balde Diao.
Inter: Handanovic; D’Ambrosio, Ranocchia, A Bastoni; Hakimi, Gagliardini, Vecino, Eriksen, Young; Alexis Sanchez, Lautaro Martinez
Sampdoria: Audero; Bereszynski, Tonelli, Colley, Augello; Candreva, Thorsby, Silva, Jankto; Ramirez; Keita Balde
Ref: Ayroldi