Inter can break away definitively in third place with Lautaro Martinez picked ahead of Mauro Icardi, but a win would put Roma into fourth.
It kicks off at San Siro at 19.30 UK time (18.30 GMT).
You can follow all the action as it happens and give your views on the LIVEBLOG.
Marcelo Brozovic is out injured, but Borja Valero has shaken off a muscular problem to start in midfield.
Inter can break away definitively in third place with Lautaro Martinez picked ahead of Mauro Icardi, but a win would put Roma into fourth.
It kicks off at San Siro at 19.30 UK time (18.30 GMT).
You can follow all the action as it happens and give your views on the LIVEBLOG.
Marcelo Brozovic is out injured, but Borja Valero has shaken off a muscular problem to start in midfield.
Matteo Politano, Ivan Perisic and ex-Roma star Radja Nainggolan fan out behind the centre-forward, which for such a big game is surprisingly Lautaro Martinez and not Icardi.
It was rumoured his form during the six-week Icardi exile had made him first choice in Luciano Spalletti’s eyes and the only reason he hadn’t started recently was due to an injury.
Roma miss Daniele De Rossi, Davide Santon and Rick Karsdorp, but Cengiz Under returns to the starting XI, as does Alessandro Florenzi.
Aleksandar Kolarov is back from suspension and Steven Nzonzi gets the nod in midfield.
Lorenzo Pellegrini is chosen instead of ex-Inter youth team player Nicolò Zaniolo.
A victory would allow Roma to leapfrog Milan into that fourth and final Champions League spot, as the Rossoneri were held to a 1-1 draw by Parma today.
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Borja Valero; Politano, Nainggolan, Perisic; Lautaro Martinez
Inter bench: Padelli, Gagliardini, Icardi, Keita, Ranocchia, Joao Mario, Cedric Soares, Miranda, Dalbert, Candreva
Roma: Mirante; Florenzi, Manolas, Fazio, Kolarov; Cristante, Nzonzi; Under, Pellegrini, El Shaarawy; Dzeko
Roma bench: Olsen, Fuzato, Juan Jesus, Perotti, Schick, Marcano, Coric, Zaniolo, Pastore, Kluivert, Riccardi
Ref: Guida