Inter choose Borja Valero, Alexis Sanchez and Romelu Lukaku upfront, as they host Arkadiusz Milik, Lorenzo Insigne and Matteo Politano’s Napoli.
It kicks off at San Siro at 20.45 UK time (19.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri need a win to keep second place, as Atalanta and Lazio went into this penultimate round just one point behind them.
Inter choose Borja Valero, Alexis Sanchez and Romelu Lukaku upfront, as they host Arkadiusz Milik, Lorenzo Insigne and Matteo Politano’s Napoli.
It kicks off at San Siro at 20.45 UK time (19.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri need a win to keep second place, as Atalanta and Lazio went into this penultimate round just one point behind them.
Roberto Gagliardini is suspended, with Stefano Sensi and Matias Vecino injured, but Stefan de Vrij and Nicolò Barella are back in the starting XI.
Despite having Christian Eriksen available, Borja Valero gets the nod in the trequartista role behind Lukaku and Alexis Sanchez, resting Lautaro Martinez.
Napoli have Dries Mertens banned, with Kostas Manolas and Fernando Llorente injured, but coach Gennaro Gattuso is also tempted into some squad rotation.
With a Europa League group stage place already secured thanks to their Coppa Italia win, the mind inevitably wanders towards their Champions League Round of 16 clash with Barcelona.
Arek Milik starts in one of his final Napoli matches, flanked by Insigne and ex-Inter winger Politano, while Diego Demme and Eljif Elmas also step in.
These sides have met three times already this season, Inter winning 3-1 at the Stadio San Paolo in Serie A, but Napoli got a 1-0 victory at San Siro and 1-1 home draw in the Coppa Italia semi-final.
Inter: Handanovic; D’Ambrosio, De Vrij, Bastoni; Candreva, Barella, Brozovic, Biraghi; Borja Valero; Alexis Sanchez, R Lukaku
Inter bench: Padelli, Berni, Godin, Lautaro Martinez, Moses, Ranocchia, Young, Eriksen, Esposito, Pirola, Agoume, Skriniar
Napoli: Meret; Hysaj, Maksimovic, Koulibaly, Mario Rui; Elmas, Demme, Zielinski; Politano, Milik, Insigne
Napoli bench: Ospina, Karnezis, Malcuit, Allan, Callejon, Fabian Ruiz, Lozano, Luperto, Di Lorenzo, Ghoulam, Younes, Lobotka
Ref: Valeri