Inter have Radja Nainggolan and Stefan de Vrij back in the starting XI with Mauro Icardi and Ivan Perisic, but Leo Messi is in the stands.
It kicks off at San Siro at 20.00 GMT.
These two sides are almost assured qualification anyway, as Tottenham Hotspur and PSV scraped just one point from the opening three games.
Inter have Radja Nainggolan and Stefan de Vrij back in the starting XI with Mauro Icardi and Ivan Perisic, but Leo Messi is in the stands.
It kicks off at San Siro at 20.00 GMT.
These two sides are almost assured qualification anyway, as Tottenham Hotspur and PSV scraped just one point from the opening three games.
As Barcelona won 2-0 at Camp Nou, that means this is a head-to-head for top spot.
Nainggolan missed that trip due to an ankle injury and De Vrij was surprisingly benched in favour of Joao Miranda, but both are back in the starting XI this evening.
Luciano Spalletti may well enact a slight change of tactics, going from the 4-2-3-1 formation to a more traditional 4-3-3 with Matteo Politano and Ivan Perisic flanking Mauro Icardi.
Inter are brimming with confidence after seven consecutive Serie A victories, including Saturday’s 5-0 thrashing of Genoa.
Barcelona brought Messi along to San Siro, but he is still not considered fit to start after breaking his arm only last month and will watch from the stands.
Rafinha scored in the first leg against his old club, where he played on loan for six months last season, but this time he is benched in favour of Ousmane Dembele.
Luis Suarez and ex-Inter man Philippe Coutinho complete the attack.
Thomas Vermaelen and Samuel Umtiti are still out injured, but Sergi Roberto is again preferred to Nelson Semedo in defence.
Inter: Handanovic; Vrsaljko, De Vrij, Skriniar, Asamoah; Vecino, Brozovic, Nainggolan; Politano, Icardi, Perisic
Inter bench: Padelli, Miranda, D'Ambrosio, Borja Valero, Candreva, Keita Baldé, Martinez
Barcelona: Ter Stegen; Sergi Roberto, Piqué, Lenglet, Jordi Alba; Rakitic, Busquets, Arthur; Dembele, Suarez, Coutinho
Barcelona bench: Cillessen, Chumi, Semedo, Vidal, Rafinha, Alena, Malcom
Ref: Marciniak (POL)