Inter throw Mauro Icardi, Marcelo Brozovic and Xherdan Shaqiri at Palermo’s Paulo Dybala and Franco Vazquez.
It kicks off at 19.45 GMT, click here for a match preview and here to follow our LIVEBLOG.
These are tough times for Roberto Mancini, who since taking over from Walter Mazzarri has a worse points per game tally than his sacked predecessor.
Inter throw Mauro Icardi, Marcelo Brozovic and Xherdan Shaqiri at Palermo’s Paulo Dybala and Franco Vazquez.
It kicks off at 19.45 GMT, click here for a match preview and here to follow our LIVEBLOG.
These are tough times for Roberto Mancini, who since taking over from Walter Mazzarri has a worse points per game tally than his sacked predecessor.
They have put together just one point from the last four games in all competition, crashing out of the Coppa Italia quarter-final to Napoli midweek.
Beaten by both Torino and Sassuolo, the Nerazzurri are desperate to get back on track in order to maintain any hope of qualifying for Europe.
Palermo were only promoted from Serie B over the summer, but currently sit four points clear of Inter, so will remain ahead of them in the table no matter what happens tonight.
Juan Jesus finally returns from a four-match ban, but Isaac Donkor is suspended with Nemanja Vidic, Marco Andreolli and Danilo D’Ambrosio sidelined.
Lukas Podolski is benched after some sluggish performances, as January signings Shaqiri and Brozovic have been more impressive.
There are even reports Inter won’t take up their option to sign Podolski on a permanent basis from Arsenal.
Instead, Icardi and Rodrigo Palacio lead the way with Shaqiri in a 4-3-3 system, surprisingly dropping Mateo Kovacic.
Palermo are heavily reliant on Argentine sensational Dybala, who has scored 11 Serie A goals this season and earned attention from the likes of Manchester United and Paris Saint-Germain.
He is partnered by Franco Vazquez, but Enzo Maresca is ruled out and Andelkovic suspended.
Italy Under-21 international striker Andrea Belotti is on the bench ready to come on, having scored the late winner last week.
Palermo have already conquered this stadium, beating Milan 2-0 in November, so can they make it a San Siro double?
It would make history, as the Sicilians have only ever got the better of Inter here in a 2-1 Coppa Italia tie in August 1980.
Their Serie A record in this fixture is eight draws and 18 defeats.
Inter: Handanovic; Santon, Ranocchia, Juan Jesus, Nagatomo; Guarin, Medel, Brozovic; Shaqiri, Icardi, Palacio
Inter bench: Carrizo, Berni, Kovacic, Podolski, Campagnaro, Kuzmanovic, Obi, Dodò, Puscas, Hernanes, Bonazzoli
Palermo: Sorrentino; Terzi, Gonzalez, Daprelà; Morganella, Rigoni, Jajalo, Barreto, Lazaar; Vazquez, Dybala
Palermo bench: Ujkani, Fulignati, Rispoli, Milanovic, Joao Silva, Emerson, Della Rocca, Bolzoni, Chochev, Quaison, Ortiz, Belotti