Inter are seeking a fourth consecutive victory under ex-Lazio Coach Stefano Pioli, but must reshuffle the midfield in this head-to-head for Europe.
It kicks off at San Siro at 19.45 GMT, follow the build-up and action while giving your views on the Liveblog.
The Nerazzurri are finally finding their form under new boss Pioli, who of course was sacked by Lazio in April, having taken them to third place the season before.
Inter are seeking a fourth consecutive victory under ex-Lazio Coach Stefano Pioli, but must reshuffle the midfield in this head-to-head for Europe.
It kicks off at San Siro at 19.45 GMT, follow the build-up and action while giving your views on the Liveblog.
The Nerazzurri are finally finding their form under new boss Pioli, who of course was sacked by Lazio in April, having taken them to third place the season before.
They’ve put together three consecutive wins between Serie A and the Europa League, keeping two straight clean sheets against Genoa and Sassuolo.
Antonio Candreva got the winning goal at the Mapei Stadium at the weekend and he starts against his former club, supporting Mauro Icardi along with Ever Banega and Ivan Perisic.
There have to be massive changes in midfield, because both Joao Mario and Felipe Melo are suspended, while Gary Medel is injured.
It gives Banega a rare chance to shine amid rumours he’ll be sold in January, and Marcelo Brozovic is joined by Geoffrey Kondogbia.
The system changes too, scrapping the three-man defence in favour of a 4-2-3-1.
Lazio have been on good form too recently, losing just one of the last 12 rounds – the Derby della Capitale against Roma – with eight wins and three stalemates.
Simone Inzaghi has practically a full squad at his disposal at San Siro, though Stefan Radu was carrying a knock and suffered a relapse during the warm-up, so Patric starts instead.
Ciro Immobile has nine Serie A goals and two assists this season, but fired blanks for the last six games, failing to find the net since October 30.
Felipe Anderson, Keita Balde Diao and Sergej Milinkovic-Savic have all been contributing support as well as goals.
Marco Parolo returns from suspension and Biglia is eager to impress, as he still hasn’t agreed a new contract and could be heading to Inter for a reunion with Pioli.
Lazio beat Inter home and away last season, but above all are unbeaten here since a 4-1 drubbing in May 2014, coming away with a 2-2 draw and 2-1 victory.
Both sides found the net in each of the last six editions of this fixture in Milan for a grand total of 22 goals.
Inter: Handanovic; D'Ambrosio, Murillo, Miranda, Ansaldi; Brozovic, Kondogbia; Candreva, Banega, Perisic; Icardi
Inter bench: Carrizzo, Yao, Andreolli, Ranocchia, Santon, Nagatomo, Gnoukouri, Palacio, Biabiany, Eder, Gabriel Barbosa
Lazio: Marchetti; Basta, De Vrij, Wallace, Radu; Parolo, Biglia, Milinkovic-Savic; Felipe Anderson, Immobile, Lulic
Lazio bench: Strakosha, Vargic, Hoedt, Radu, Bastos, Murgia, Cataldi, Lombardi, Kishna, Luis Alberto, Keita, Djordjevic