Inter and Fiorentina go head-to-head for the top of the table with Stevan Jovetic facing his former club.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
The Nerazzurri have a 100 per cent record after their best start for 49 years, but the Viola are only three points behind and including last season have won nine out of 10 Serie A games.
Inter and Fiorentina go head-to-head for the top of the table with Stevan Jovetic facing his former club.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
The Nerazzurri have a 100 per cent record after their best start for 49 years, but the Viola are only three points behind and including last season have won nine out of 10 Serie A games.
Roberto Mancini, a former Fiorentina Coach, has been criticised for the somewhat clinical approach that gave them four 1-0 results and a 2-1 away to Carpi.
Danilo D’Ambrosio is out after sustaining minor injuries in a car crash on Friday, while Jeison Murillo is also sidelined.
Jovetic, Mauro Icardi and Ivan Perisic lead the line, with Felipe Melo another ex-Viola player in midfield.
Montenegro international Jo-Jo scored 35 goals in 116 appearances for the Tuscans.
Fiorentina must do without Manuel Pasqual and Marko Bakic, but hope Jakub Blaszczykowski can build on his debut Serie A goal.
Josip Ilicic and Borja Valero provide support for Nikola Kalinic, so Giuseppe Rossi is ready to come off the bench when needed.
Federico Bernardeschi and Nenad Tomovic had been expected to start, but they are bumped down.
The Tuscans had lost 12 consecutive visits to San Siro until a 1-0 result in March 2014 ended that hoodoo.
This fixture hasn’t ended with a share of the spoils since the thrilling 2-2 in November 1996.
Inter: Handanovic; Santon, Miranda, Medel, Telles; Guarin, Felipe Melo, Kondogbia; Perisic, Jovetic, Icardi
Inter bench: Carrizo, Juan Jesus, Palacio, Biabiany, Montoya, Ljajic, Ranocchia, Gnoukouri, Nagatomo, Brozovic, Dimarco, Manaj
Fiorentina: Tatarusanu; Roncaglia, Gonzalo Rodriguez, Astori; Blaszczykowski, Badelj, Vecino, Alonso; Ilicic, Borja Valero; Kalinic
Fiorentina bench: Sepe, Lezzerini, Gilberto, Tomovic, Bernardeschi, Rebic, Mati Fernandez, Suarez, Verdù, Rossi, Babacar