Thiago Motta makes his debut on the Genoa bench in a relegation battle with Brescia, who start his former Inter teammate Mario Balotelli.
It kicks off at the Stadio Luigi Ferraris, commonly known as Marassi, at 19.45 UK time (18.45 GMT).
You can follow the build-up and action as it happens from this game and Inter-Parma on the LIVEBLOG.
Thiago Motta makes his debut on the Genoa bench in a relegation battle with Brescia, who start his former Inter teammate Mario Balotelli.
It kicks off at the Stadio Luigi Ferraris, commonly known as Marassi, at 19.45 UK time (18.45 GMT).
You can follow the build-up and action as it happens from this game and Inter-Parma on the LIVEBLOG.
Aurelio Andreazzoli was sacked after picking up just one point from the last six rounds, culminating in a 5-1 thrashing at the hands of Parma.
The chosen man was 37-year-old Thiago Motta, a former Genoa and Inter midfielder whose only management experience is a spell at the Paris Saint-Germain youth team.
Curiously, Thiago Motta was teammates with both Genoa striker Goran Pandev and Brescia forward Balotelli during his time at Inter.
Domenico Criscito, Andrea Favilli, Marko Pajac and Stefano Sturaro are out of action, but Thiago Motta changes to a 4-3-3 formation with Pandev and Christian Kouame benched.
Instead, Francesco Cassata and Sinan Gumus flank Andrea Pinamonti.
Brescia miss Ernesto Torregrossa, Bruno Martella, Luca Tremolada, Giangiacomo Magnani and Daniele Dessena, the latter stretchered off in tears after a serious ankle injury during the 0-0 draw with Fiorentina on Monday.
Nikolas Spalek is chosen to take the trequartista role behind Balotelli and Florian Aye, as Alfredo Donnarumma is still not 100 per cent fit.
Romulo is moved back to his more traditional deeper midfield position with Italy international Sandro Tonali.
The Rondinelle have seven points in seven matches, but a game in hand to be played against Sassuolo in December.
Brescia can equal the club record of four clean sheets in their first eight rounds of the Serie A season, set in 1966-67 and 1992-93.
Genoa: Radu; Ghiglione, Romero, C Zapata, Ankersen; Schone, Radovanovic, Lerager; Cassata, Pinamonti, Gumus
Brescia: Joronen; Sabelli, Cistana, Chancellor, Mateju; Bisoli, Tonali, Romulo; Spalek; Aye, Balotelli
Ref: Abisso