It’s a challenge between two deeply unpredictable teams tonight, as Lazio visit revamped Genoa.
It kicks off at Marassi at 19.45 GMT, follow all the action as it happens on our LIVEBLOG.
Lazio finished third last season, but this time round even Europa League qualification will be a push.
Alessandro Matri starts his ban, while Antonio Candreva, Milan Bisevac, Ricardo Kishna, Lucas Biglia, Stefan Radu and Stefan de Vrij are sidelined.
It’s a challenge between two deeply unpredictable teams tonight, as Lazio visit revamped Genoa.
It kicks off at Marassi at 19.45 GMT, follow all the action as it happens on our LIVEBLOG.
Lazio finished third last season, but this time round even Europa League qualification will be a push.
Alessandro Matri starts his ban, while Antonio Candreva, Milan Bisevac, Ricardo Kishna, Lucas Biglia, Stefan Radu and Stefan de Vrij are sidelined.
Filip Djordjevic takes the centre-forward role flanked by Felipe Anderson and Stefano Mauri, while Sergej Milinkovic-Savic and Danilo Cataldi return from suspension to bolster the midfield.
Genoa stick to their preferred 3-4-3 formation and have a full squad to choose from, as January buys Tim Matavz and Gabriel Silva are on the bench.
Suso completes the trident attack with Leonardo Pavoletti and Alessio Cerci.
Genoa have a surprisingly excellent record in this fixture, winning eight consecutive meetings – home and away – before a 2-0 defeat at the Olimpico in September.
These sides haven’t played out a stalemate since the 0-0 at Marassi in January 2011.
Lazio’s last victory in Genoa was 2-1 in April 2010, followed by a draw and four consecutive defeats.
Genoa: Perin; Munoz, Burdisso, Izzo; Ansaldi, Rincon, Dzemaili, Laxalt; Cerci, Pavoletti, Suso
Genoa bench: Lamanna, Marchese, De Maio, Gabriel Silva, Fiamozzi, Tachtsidis, Donnarumma, Rigoni, Ntcham, Capel, Lazovic, Pandev, Matavz
Lazio: Marchetti; Basta, Mauricio, Hoedt, Konko; Milinkovic-Savic, Cataldi, Parolo; Felipe Anderson, Djordjevic, Mauri
Lazio bench: Berisha, Guerrieri, Gentiletti, Patric, Braafheid, Lulic, Keita, Klose