Zlatan Ibrahimovic returns to the starting XI after three weeks, joined by Sandro Tonali and Brahim Diaz, while Fiorentina rely on Dusan Vlahovic and Franck Ribery.
It kicks off at the Stadio Artemio Franchi at 17.00 GMT.
Zlatan Ibrahimovic returns to the starting XI after three weeks, joined by Sandro Tonali and Brahim Diaz, while Fiorentina rely on Dusan Vlahovic and Franck Ribery.
It kicks off at the Stadio Artemio Franchi at 17.00 GMT.
The Rossoneri now have only Serie A to focus on after their Europa League exit to Manchester United on Thursday evening.
Ante Rebic begins his two-match ban, but wouldn’t be available anyway, as he is injured along with Rafael Leao, Davide Calabria, Alessio Romagnoli, Mario Mandzukic and Daniel Maldini.
Ibrahimovic returns to the starting XI for the first time in almost a month, having been a substitute midweek, and he is supported by Brahim Diaz, Hakan Calhanoglu and Alexis Saelemaekers.
Sandro Tonali and Diogo Dalot also step back into the line-up, while Jens Petter Hauge is available from the bench.
Fiorentina miss defender Igor and striker Aleksandar Kokorin, but Christian Kouame and Sofyan Amrabat are not at 100 per cent.
Giacomo Bonaventura faces his former club, with Ribery and on-form Dusan Vlahovic upfront.
Fiorentina: Dragowski, Martinez Quarta, Milenkovic, Pezzella; Caceres, Bonaventura, Pulgar, Castrovilli, Eysseric; Ribery, Vlahovic.
Milan: Donnarumma, Dalot, Kjaer, Tomori, Hernandez, Tonali, Kessie, Saelemaekers, Calhanoglu, Diaz, Ibrahimovic
Ref: Guida