Juventus saw their perfect record terminated by Genoa last week and keep squad rotation to a minimum for this trip to Empoli.
It kicks off at the Stadio Castellani at 17.00 UK time (16.00 GMT).
Follow the build-up and action as it happens from this game, Atalanta-Parma and Torino–Fiorentina on the LIVEBLOG.
Juventus saw their perfect record terminated by Genoa last week and keep squad rotation to a minimum for this trip to Empoli.
It kicks off at the Stadio Castellani at 17.00 UK time (16.00 GMT).
The Bianconeri have won every single match played in Serie A and the Champions League so far this season, with one exception – the surprise 1-1 home stalemate with Genoa.
That was a result of their complacency and wasteful finishing, so Max Allegri will do everything to ensure there isn’t a repeat in Tuscany.
He chooses more or less the same side that beat Manchester United 1-0 at Old Trafford on Tuesday evening, with Cristiano Ronaldo, Paulo Dybala and Federico Bernardeschi stepping in for Juan Cuadrado.
CR7 has participated in eight of Juve’s last 12 Serie A goals, scoring five and assisting three.
In the absence of injured Mario Mandzukic, Sami Khedira and Emre Can, Rodrigo Bentancur continues to hold the midfield fort, but Mattia De Sciglio gives Joao Cancelo a rest.
Giorgio Chiellini was named in the starting XI and had a problem in the warm-up, so Daniele Rugani faces his former club instead.
Empoli have put in some very impressive performances so far this season, but the results simply haven’t matched up to their style of football.
Much of the issue is in attack, where Antonino La Gumina has been relatively toothless.
The ex-Palermo striker is dropped in favour of veteran Ciccio Caputo, with Miha Zajc and Rade Krunic in a dual trequartista role.
Frederic Veseli, Levan Mchedlidze and Alejandro Rodriguez miss out, while Salih Ucan is ready to come off the bench after scoring in last week’s thrilling 3-3 draw with Frosinone.
Empoli haven’t beaten Juventus in Serie A since a 1-0 result at the Castellani in April 1999, followed by two draws and 12 defeats, home and away.
Meanwhile, the Old Lady haven’t lost in their last 17 away league matches, winning 14 of them.
Empoli: Provedel; Di Lorenzo, Silvestre, Maietta, Antonelli; Acquah, Traore, Bennacer; Krunic, Zajc; Caputo
Juventus: Szczesny; De Sciglio, Bonucci, Rugani, Alex Sandro; Bentancur, Pjanic, Matuidi; Bernardeschi, Dybala, Cristiano Ronaldo
Ref: Calvarese