Lazio look to Ciro Immobile, Joaquin Correa and Sergej Milinkovic-Savic for a difficult Europa League trip to Eintracht Frankfurt.
It kicks off at 20.00 UK time (19.00 GMT).
Lazio look to Ciro Immobile, Joaquin Correa and Sergej Milinkovic-Savic for a difficult Europa League trip to Eintracht Frankfurt.
It kicks off at 20.00 UK time (19.00 GMT).
The Biancocelesti won their opening tie against Apollon Limassol, one of five consecutive victories in all competition, but that ground to a halt on Saturday in a 3-1 defeat to arch rivals Roma.
Simone Inzaghi has to put the Derby della Capitale setback out of their minds and focus on the most difficult test of this group phase, a visit to German Cup winners Eintracht Frankfurt.
Ciro Immobile starts rather than Felipe Caicedo, while Joaquin Correa is chosen ahead of Luis Alberto in a largely full-strength side.
Milinkovic-Savic starts with Lucas Leiva and former Real Betis wing-back Riza Durmisi.
Eintracht must do without suspended left-back Jetro Willems, with captain David Abraham and defender Carlos Salcedo out injured.
Their striker Ante Rebic is familiar to Serie A fans for his time at Fiorentina, albeit on the bench today, while goalkeeper Kevin Trapp was at Paris Saint-Germain.
Eintracht Frankfurt: Trapp; Da Costa, Hasebe, Russ, Falette; Gacinovic, De Guzman, Torro, Kostic; De Souza; Jovic, Haller
Eintracht bench: Rönnow, N'Dicka, Rebic, Fernandes, Stendera, Muller, Twatha
Lazio: Proto; Luiz Felipe, Acerbi, Wallace; Basta, Parolo, Leiva, Milinkovic-Savic, Durmisi; Correa; Immobile
Lazio bench: Guerrieri, Berisha, Rossi, Luis Alberto, Bastos, Lulic, Badelj