Sassuolo are forced to revamp without Domenico Berardi and Francesco Magnanelli, while Cagliari lose Radja Nainggolan and drop Giovanni Simeone.
It kicks off at the Sardegna Arena at 18.30 UK time (17.30 GMT).
You can follow all the build-up and action as it happens from this game, Verona–Atalanta and Milan–Bologna on the LIVEBLOG.
Sassuolo are forced to revamp without Domenico Berardi and Francesco Magnanelli, while Cagliari lose Radja Nainggolan and drop Giovanni Simeone.
It kicks off at the Sardegna Arena at 18.30 UK time (17.30 GMT).
Sassuolo have been hitting the headlines lately with some spectacular matches, not least the fightback from 2-0 down to lead Juventus 3-2, eventually drawing 3-3.
That was their third 3-3 result since the restart and a sign of what Roberto De Zerbi hopes to achieve next season.
However, Berardi, Magnanelli and Medhi Bourabia are all suspended this evening, with Gregoire Defrel, Pedro Obiang and Filippo Romagna injured.
Lukas Haraslin therefore steps in to the trio supporting Ciccio Caputo, with Jeremie Boga and Filip Djuricic, while Hamed Junior Traore joins Manuel Locatelli in midfield.
Rogerio is also a surprise starter, as he was only taken to hospital a few days ago after a knock to the head in training.
Cagliari are stuttering under new coach Walter Zenga, managing just three draws in the last five rounds, including a 3-0 humiliation at the hands of Sampdoria midweek.
Losing Nainggolan to injury probably for the rest of the season was a heavy blow, with Luca Pellegrini, Leonardo Pavoletti and Luca Cigarini also out of action.
Midfielder Ionita is suspended today, so Paolo Faragò comes in with Federico Mattiello in a more advanced wide role.
Gaston Pereiro is given a rare start, but it is surprisingly in place of Giovanni Simeone, as Joao Pedro is his strike partner.
Cagliari have not beaten Sassuolo in Serie A since December 2016, that 4-3 thriller followed by three draws and as many defeats.
Cagliari: Cragno; Pisacane, Ceppitelli, Carboni; Faragò, Nandez, Birsa, Rog, Mattiello; Pereiro, Joao Pedro
Sassuolo: Pegolo; Muldur, Marlon, Ferrari, Rogerio; Locatelli, Traore; Haraslin, Djuricic, Boga; Caputo
Ref: Ayroldi