Napoli rely on Dries Mertens, Eljif Elmas and Jose Callejon for their head-to-head with Cagliari, who miss Radja Nainggolan and start Gaston Pereiro.
It kicks off at the Sardegna Arena at 17.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
There are only two points separating these sides going into the weekend, so it’s a face-off for potential European positions.
Napoli rely on Dries Mertens, Eljif Elmas and Jose Callejon for their head-to-head with Cagliari, who miss Radja Nainggolan and start Gaston Pereiro.
It kicks off at the Sardegna Arena at 17.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
There are only two points separating these sides going into the weekend, so it’s a face-off for potential European positions.
Cagliari started the season strong and then fell away badly, as they are without a victory since December 2, winless in 10 games between Serie A and the Coppa Italia.
Star man Nainggolan is suspended, with ex-Napoli midfielder Marko Rog, Leonardo Pavoletti, Fabrizio Cacciatore and Paolo Faragò injured.
It means January signing from PSV Eindhoven Gaston Pereiro gets his first start in support of Joao Pedro and Giovanni Simeone.
Napoli are a deeply unpredictable side under Gennaro Gattuso, capable of beating Juventus in Serie A and Inter in the Coppa Italia semi-final, along with a home defeat to Lecce.
Arkadiusz Milik, Kalidou Koulibaly, Hirving Lozano and Kevin Malcuit are injured, while Gattuso announced in his press conference that he had left Allan at home because the Brazilian was “walking” through training sessions.
That means the trident upfront is Jose Callejon, Dries Mertens and Eljif Elmas.
Insigne, was not fit enough to start the midweek Coppa Italia triumph with Inter due to a bruised knee and is again only on the bench.
January signing Diego Demme takes control of the midfield with Fabian Ruiz and Piotr Zielinski.
Cagliari: Cragno; Pisacane, Walukiewicz, Klavan, Pellegrini; Nandez, Cigarini, Ionita; Pereiro; Joao Pedro, Simeone
Napoli: Ospina; Di Lorenzo, Manolas, Maksimovic, Hysaj; Fabian Ruiz, Demme, Zielinski; Callejon, Mertens, Elmas
Ref: Doveri