Cagliari rely on Radja Nainggolan, Joao Pedro and Giovanni Simeone as they go head-to-head with Ciro Immobile’s Lazio for a top four spot.
It kicks off at the Sardegna Arena at 19.45 GMT.
You can follow all the build-up and action as it happens and give your views on the LIVEBLOG.
Cagliari rely on Radja Nainggolan, Joao Pedro and Giovanni Simeone as they go head-to-head with Ciro Immobile’s Lazio for a top four spot.
It kicks off at the Sardegna Arena at 19.45 GMT.
You can follow all the build-up and action as it happens and give your views on the LIVEBLOG.
The Sardinians can catch Roma in fourth place with a victory, while a win would put third-place Lazio within three points of joint leaders Juventus and Inter.
Cagliari still have ex-Roma goalkeeper Robin Olsen suspended following his clash with Lecce’s Gianluca Lapadula, so Rafael is again in goal, but ex-Napoli midfielder Marko Rog is banned too.
Valter Birsa, Alessio Cragno, Luca Ceppitelli and Leonardo Pavoletti are all injured, with Lucas ‘Pata’ Castro not 100 per cent fit.
The star man is inevitably Nainggolan, who faced Lazio many times in the derby for Roma, with Uruguay international Nahitan Nandez by his side.
Joao Pedro and former Fiorentina striker Simeone lead the attack.
Lazio crashed out of the Europa League in the group phase, so are focusing all their attention on Serie A and gaining an eighth consecutive victory.
Coach Simone Inzaghi must also prepare for Sunday’s Italian Super Cup against Juventus in Riyadh.
Immobile is runaway Capocannoniere with 17 goals in just 15 Serie A appearances this season.
He is supported by Joaquin ‘Tucu’ Correa, Luis Alberto and Sergej Milinkovic-Savic.
Jordan Lukaku and Denis Vavro are on the treatment table.
There are concerns for Francesco Acerbi, Senad Lulic, Lucas Leiva and Marco Parolo, because they are one yellow card away from suspension.
As the next Lega Serie A organised match is the Supercoppa, it means a booking would rule them out of the Juventus trophy dash.
Cagliari: Rafael; Cacciatore, Klavan, Pisacane, Lykogiannis; Nandez, Cigarini, Ionita; Nainggolan; Joao Pedro, Simeone
Cagliari bench: Aresti, Ciocci, Pinna, Mattiello, Faragò, Deiola, Pellegrini, Walukievicz, Oliva, Cerri, Ragatzu
Lazio: Strakosha; Luiz Felipe, Acerbi, Radu; Lazzari, Milinkovic-Savic, Lucas Leiva, Luis Alberto, Lulic; Correa, Immobile
Lazio bench: Proto, Guerrieri, Bastos, Patric, Parolo, Cataldi, Berisha, Marusic, Jony, André Anderson, Adekanye, Caicedo
Ref: Maresca