Atalanta are without Josip Ilicic, but start Mario Pasalic, Duvan Zapata and Papu Gomez, as a victory over Udinese would put them in the Champions League places.
It kicks off in Bergamo at 18.00 UK time (17.00 GMT).
You can follow all the build-up and action as it happens from this game and Fiorentina–Sassuolo on the LIVEBLOG.
Atalanta are without Josip Ilicic, but start Mario Pasalic, Duvan Zapata and Papu Gomez, as a victory over Udinese would put them in the Champions League places.
It kicks off in Bergamo at 18.00 UK time (17.00 GMT).
It has been quite a week for Atalanta, who on Thursday secured their place in the Coppa Italia Final by beating Fiorentina 2-1 and will face Lazio on May 17.
Now other results have gone their way, as Milan lost to Torino and Roma beat Cagliari, meaning a victory here would catapult Atalanta clear into fourth place on 59 points.
It’d push Roma down to fifth, with Torino in front of Milan on 56 due to a superior head-to-head record.
Duvan Zapata scored a hat-trick when Atalanta beat Udinese 3-1 earlier this season and he again leads the attack, as well as challenging for Capocannoniere status.
Ilicic is still struggling with that recurring knee injury and is not even risked on the bench, so Pasalic supports captain Alejandro ‘Papu’ Gomez.
Gianluca Mancini returns to defence, while Hans Hateboer was suspended midweek in the Coppa, but Rafael Toloi is out for the rest of the season.
Udinese need a result too, as they are in the last spot before the relegation zone, four points clear of Empoli.
If they were to stun Atalanta and win in Bergamo, they’d leapfrog Genoa in the table and move to within a point of Bologna, but more importantly seven points away from the drop zone.
Bram Nuytinck returns from injury for a spot on the bench, but Seko Fofana and William Troost-Ekong join the absentee list, with Nicolas Opoku, Valon Behrami and Antonin Barak.
Wing-back Jens Stryger-Larsen therefore improvises in a three-man defence.
Ignacio Pussetto and Kevin Lasagna get the nod in attack, moving Rodrigo De Paul to a deeper role and benching Stefano Okaka.
Udinese have won only one of their last 16 away games, losing 10 of them.
Atalanta: Gollini; Mancini, Palomino, Masiello; Hateboer, Freuler, De Roon, Gosens; Pasalic; Gomez, Duvan Zapata
Atalanta bench: Berisha, Rossi, Reca, Piccoli, Djimsiti, Castagne, Pessina, Peli, Ibanez, Colpani, Cambiaghi
Udinese: Musso; Stryger-Larsen, De Maio, Samir; D’Alessandro, De Paul, Sandro, Mandragora, Zeegelaar; Lasagna, Pussetto
Udinese bench: Perisan, Nicolas, Okaka, Badu, Micin, Nuytinck, Hallfredsson, Wilmot, Teodorczyk
Ref: Giacomelli