Atalanta must beat Dinamo Zagreb or say goodbye to any lingering Champions League ambitions, so Luis Muriel and Papu Gomez lead the attack.
It kicks off at San Siro at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Juventus-Atletico Madrid on the LIVEBLOG.
Atalanta must beat Dinamo Zagreb or say goodbye to any lingering Champions League ambitions, so Luis Muriel and Papu Gomez lead the attack.
It kicks off at San Siro at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Juventus-Atletico Madrid on the LIVEBLOG.
Gian Piero Gasperini’s men have struggled to sustain two major tournaments, especially as Duvan Zapata is still out of action, seven weeks since suffering a thigh injury while on international duty with Colombia.
They lost their historic first ever Champions League match 4-0 in Zagreb and have since managed just one point, holding 10-man Manchester City to a 1-1 draw.
Gasp changes his usual routine and starts Luis Muriel with Papu Gomez and Mario Pasalic, leaving Josip Ilicic on the bench.
Simon Kjaer takes over in defence from Berat Djimsiti, in part because the Albania international is shaken by the earthquake in his homeland.
Dinamo Zagreb are without suspended midfielder Nikola Moro, while Marko Leskovic, Komnen Andric and Sandro Kulenovic are injured.
Midfielders Arijan Ademi needed a fitness test to start with Dani Olmo, who is reportedly being watched by Milan talent scouts this evening, but Amer Gojak isn’t ready.
Bruno Petkovic was dismal during his time in Serie A and B, but has really found his scoring boots in Zagreb.
Mislav Orsic is the man to watch, though, as he scored a hat-trick against Atalanta last time out.
In order to take on this crucial match, Dinamo Zagreb move to a three-man defence to mirror Atalanta.
Atalanta: Gollini; Toloi, Palomino, Kjaer; Hateboer, De Roon, Freuler, Gosens; Pasalic; Gomez, Muriel
Atalanta bench: Sportiello, Masiello, Malinovskyi, Djimsiti, Castagne, Ilicic, Barrow
Dinamo Zagreb: Livakovic; Theophile-Catherine, Dilaver, Peric; Stojanovic, Olmo, Ivanusec, Ademi, Leovac; Orsic, Petkovic
Dinamo bench: Zagorac, Gavranovic, Gojak, Situm, Moubandje, Dira, Kadzior
Ref: Karasev (RUS)