Inter aim to build momentum and end their Atalanta taboo, but Mauro Icardi is ruled out by illness.
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Roberto Mancini received a real boost by beating Palermo 3-0 last week, but the Nerazzurri are still in the bottom half of the table.
They have a famously terrible record in the Lombardy Derby, failing to conquer Bergamo since Mancio was last in charge seven years ago.
Inter aim to build momentum and end their Atalanta taboo, but Mauro Icardi is ruled out by illness.
It kicks off at 14.00 GMT, click here to follow our LIVEBLOG.
Roberto Mancini received a real boost by beating Palermo 3-0 last week, but the Nerazzurri are still in the bottom half of the table.
They have a famously terrible record in the Lombardy Derby, failing to conquer Bergamo since Mancio was last in charge seven years ago.
That 2-0 result was followed by three 1-1 draws and two Atalanta wins.
Yuto Nagatomo, Marco Andreolli, Jonathan and Danilo D’Ambrosio are all out of action, while Icardi is not risked after coming down with a stomach bug.
Xherdan Shaqiri has been very impressive since arriving from Bayern Munich in January and he is the one to watch.
Marcelo Brozovic and Davide Santon start again, but Mateo Kovacic is benched.
Atalanta gave Fiorentina a scare last week, beaten only in the final minute during a 3-2 thriller.
Cristian Raimondi, Boukary Drame, Niccolo Cherubin and Marcelo Estigarribia are ruled out.
Chile international Mauricio Pinilla is picked instead of German Denis, supported by Maxi Moralez and Alejandro ‘Papu’ Gomez.
Atalanta: Sportiello; A Masiello, Stendardo, Benalouane, Bellini; Zappacosta, Cigarini, Carmona, Gomez; Maxi Moralez; Pinilla
Atalanta bench: Avramov, Del Grosso, Scaloni, D'Alessandro, Migliaccio, Bianchi, Baselli, Denis, Biava, Emanuelson, Grassi, Boayke
Inter: Handanovic; Campagnaro, Ranocchia, Juan Jesus, Santon; Guarin, Medel, Brozovic; Shaqiri; Podolski, Palacio
Inter bench: Carrizo, Berni, Kovacic, Vidic, Kuzmanovic, Obi, Dodò, Puscas, Donkor, Hernanes