Lazio have Ciro Immobile back but must replace Francesco Acerbi against Inter, who are hoping to have Lautaro Martinez available.
Simone Inzgahi returns to the Olimpico for the first time since leaving Lazio, and he hopes to have Lautaro Martinez available for the big game in Rome.
The Aquile coach Maurizio Sarri has asked for a reaction after the 3-0 defeat to Bologna before the international break, but Francesco Acerbi is suspended.
Ciro Immobile should be back in the starting line-up for the home side and Patric seems set to start in the heart of the defence with Luiz Felipe.
Adam Marusic and Manuel Lazzari are fighting to take place at right for the home side.
Inzaghi has not called up Stefano Sensi, Arturo Vidal or Alexis Sanchez, and there’s doubt regarding the late return of the other South Americans.
The defence should be the usual, while Matteo Darmian and Federico Dimarco could play out wide.
Inter hope to have Lautaro Martinez ready for the game and his conditions are being assessed after the trip with Argentina.
The verdict regarding Lautaro will change the line-up completely, as Ivan Perisic is expected to replace him up front if needed.
Probable line-ups: Lazio vs. Inter
Lazio (4-3-3): Reina; Marusic, Luiz Felipe, Patric, Hysaj; Milinkovic-Savic, Leiva, Luis Alberto; Felipe Anderson, Immobile, Pedro
Inter: (3-5-2): Handanovic; Skriniar, De Vrij, Bastoni;Darmian, Barella, Brozovic, Gagliardini, Dimarco; Perisic, Dzeko
Why Leiva again and not Basic?!