Dusan Vlahovic and Kenan Yildiz will lead the Juventus attack against Paulo Dybala’s Roma, but Matias Soulé is expected to start on the bench.
It kicks off at 20:45 CET (18:45 GMT) at the Stadio Olimpico in Rome.
The Bianconeri are without the injured Timothy Weah, Khephren Thuram, Arkadiusz Milik and Vasilije Adžić. New signings Teun Koopmeiners, Nico Gonzalez and Francisco Conceiçao start on the bench, so Motta is expected to use the same line-up as against Hellas Verona on Monday.
Therefore, Nicolò Savona will start at right-back, and Andrea Cambiaso will play as an attacking winger. Douglas Luiz should once again start on the bench, making room for Nicolò Fagioli and Manuel Locatelli.
Roma are without the injured Enzo Le Fèe and Daniele De Rossi is likely to pick a 3-5-2 formation with new signing Alexis Saelemaekers starting on the left flank and Soulé on the bench.
Bryan Cristante is expected to start in central midfield joining his compatriot Lorenzo Pellegrini and the Argentinean Leandro Paredes in the middle of the park.
Juventus vs Roma – how to watch on TV
Juventus-Roma is on Paramount+ in the USA. Fans in the UK and Ireland can watch it on TNT Sports or OneFootball for £4.99. beIN SPORTS 1 or beIN SPORTS CONNECT are your places to go if you want to watch the game from Australia or New Zealand.
Juventus vs Roma – probable line-ups
Juventus (4-2-3-1): Di Gregorio; Savona, Bremer, Gatti, Cabal; Locatelli, Fagioli; Cambiaso, Yildiz, Mbangula; Vlahovic.
Roma (3-5-2): Svilar; Mancini, Ndicka, Angelino; Celik, Cristante, Paredes, Pellegrini, Saelemaekers; Dybala, Dovbyk.