Juventus striker Dusan Vlahovic gets his first start of the World Cup for Serbia alongside five other Serie A players in the showdown with Switzerland.
The final Group G match kicks off at 19.00 GMT, with Brazil already qualified for the Round of 16.
There are six Serie A players in the starting XI for Serbia, including for the first time Vlahovic, who was only able to play as a substitute after arriving in Qatar from Juventus already carrying a recurring groin injury.
Coach Dragan Stojkovic said that there had been vast improvements in his fitness levels over the last few days and Vlahovic does indeed start alongside Aleksandar Mitrovic.
Meanwhile, Juve defender Gleison Bremer starts for Brazil against Cameroon in the other game.
Serbia: V Milinkovic-Savic; Milenkovic, Veljkovic, Pavlovic; Zivkovic, Lukic, S Milinkovic-Savic, Kostic; Tadic; Mitrovic, Vlahovic
Switzerland: Kobel; Widmer, Akanji, Schar, Rodriguez; Freuler, Xhaka; Shaqiri, Sow, Vargas; Embolo.