Juventus will look to Dusan Vlahovic in a home Serie A match against Cagliari, but Thiago Motta could also pick Douglas Luiz in the middle of the park.
It kicks off at 12:30 CET (10:30 GMT) at the Allianz Stadium in Turin.
Juventus beat RB Leipzig in the Champions League on Wednesday night but lost Gleison Bremer and Nico Gonzalez to injuries. Arkadiusz Milik and Vasilije Adzic are also unavailable for the Old Lady.
Pierre Kalulu and Federico Gatti are expected to start in central defence, while Nicolò Fagioli will likely go on the bench again despite an impressive performance in Germany earlier this week.
Manuel Locatelli is expected to start in the middle of the park, where Douglas Luiz is favourite over Khephren Thuram and Weston McKennie. Francisco Conceiçao will replace Nico Gonzalez on the right flank.
Vlahovic, who has scored four goals in the last two games across all competitions, will start in attack.
Juventus vs Cagliari – where to watch on TV
Juventus-Cagliari is available on OneFootball for fans in the UK and Ireland. It will be broadcast live on Paramount+ in the USA. For fans in New Zealand and Australia, it is available on BeIN SPORTS and BeIN SPORTS Connect.
Juventus vs Cagliari – probable line-ups
Juventus (4-2-3-1): Di Gregorio; Savona, Kalulu, Gatti, Cambiaso; Locatelli, Douglas Luiz; Conceicao, Koopmeiners, Yildiz; Vlahovic.
Cagliari (4-2-3-1): Scuffet; Zappa, Mina, Luperto, Obert; Makoumbou, Adopo; Zortea, Viola, Luvumbo; Piccoli.