Italy could match the all-time record by going 30 games unbeaten today, a run set during the 1930s.
The Azzurri take on Wales at the Stadio Olimpico in Rome at 17.00 UK time (16.00 GMT).
You can follow the build-up and action as it happens on the LIVEBLOG.
Roberto Mancini’s men are unbeaten in 29 fixtures, going back to a 1-1 draw with Ukraine on October 10, 2018.
If they avoid defeat to Wales, they will not only guarantee top spot in Euro 2020 Group A, but also equal the record set by Vittorio Pozzo.
That Italy was unbeaten for 30 games from November 24, 1935 through to July 20, 1939.
During that period, the Azzurri won three tournaments, specifically the International Cup, the 1936 Olympics and the 1938 World Cup.
They amassed 24 victories and six draws, although only 13 of those games were competitive in nature.
The current Italy side is unbeaten since a Nations League loss to Portugal on September 10, 2018.
That was followed by 24 wins and five draws, of which 23 were competitive fixtures and only six friendlies.
Mancini’s men have won their last 10 in a row, all with clean sheets.