The preliminary round was already completed on July 30 and 31, but the competition proper begins tomorrow.
Several Serie A clubs are involved as well as those from Serie B and Serie C participants Feralpisalò, who caused an upset by eliminating Serie B side Sudtirol 3-1.
Among the most intriguing fixtures are the local derby Modena-Sassuolo and a fascinating clash between Torino and newly-promoted Serie B fallen giants Palermo, who are now owned by City Group.
Verona-Bari also ought to be a high-profile encounter, while Salernitana-Parma, Monza-Frosinone and Genoa-Benevento involve big fanbases.
All these games will be one-off fixtures, decided after 90 minutes, or if needed extra time and penalties.