Inter coach Simone Inzaghi is confident they will be able to get the job done against Sassuolo, even though Marcelo Brozovic is a big miss in midfield.
It kicks off at 17.00 GMT at San Siro.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
Serie A Liveblog: Fiorentina-Atalanta, Venezia-Genoa, Inter-Sassuolo, Udinese-Lazio
With Milan held to a 2-2 draw by bottom club Salernitana last night, it means a win today would send Inter back on top of the table, with a game still in hand.
It would be a boost after their 2-0 Champions League midweek defeat to Liverpool.
“We had three good days of training, tried to recover energy both physical and mental to prepare for today’s difficult test,” Inzaghi told DAZN.
There are changes forced, with Brozovic and Alessandro Bastoni suspended, so Nicolò Barella has to take the Croatian’s usual creative role.
“Everyone knows how important Marcelo is in our style, but we had many other important absentees this season. I trust the squad and they will do well.”
The Neroverdi held Roma 2-2 last week, despite missing strikers Gianluca Scamacca and Giacomo Raspadori, who both return today at San Siro.
“Sassuolo have a very competitive squad, we must keep an eye on their forwards, but also elsewhere. They are a quality side who play well in spaces.”